CAS: 5708-19-0; (S)-Cyclohex-3-Enecarboxylic Acid

相似化合物

4771-80-6 5709-98-8 1679-51-2

上下游产品

CAS号67976-82-3 3-Cyclohexene-1... | CAS号131556-48-4 (S)-cyclohex-3-... | CAS号4771-80-6 3-环己烯-1-甲酸 | CAS号6493-77-2 甲基 3-环己烯-1-甲酸酯 | CAS号5709-99-9 (R)-1-C-(1-Cycl... | CAS号5709-98-8 (R)-3-环己烯甲酸 | CAS号15111-56-5 3-环己烯-1-羧酸乙酯 | CAS号163812-78-0 (1R,4S)-4-(phen...

(R)-(+)-Methyl 3-Cyclohexene-1-Carboxylate置于盐酸,水,1,8-二氮杂双环[5.4.0]十一碳-7-烯,Sodium Hydroxide体系中,用 甲醇,甲基叔丁基醚,水,N,N-二甲基甲酰胺,丙酮 作为反应溶剂,化学反应 58.0H,反应生成 (S)-(-)-3-环己烯甲酸
参考文献:Process For Producing Optically Active Carboxylic Acid
标题:Process For Producing Optically Active Carboxylic Acid
摘要:已经要求提供一个工业生产中间体的过程,该中间体对激活的血凝血因子x具有抑制作用,并且可作为预防和/或治疗血栓性疾病的药物.本发明提供了一种生产(R-α-苯乙胺盐)的过程,该盐由(S)-3-环己烯-1-羧酸和(R)-α-苯乙胺在水和丙酮的混合溶剂或水和乙酸乙酯的混合溶剂中反应而成.

专利信息

专利号:US-2015239909-A1
优先权日:2012-11-23
标 题 :Process for the preparation of (1s,4s,5s)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one
发明人：NAKAMURA YOSHITAKA; MUKESH Kumar Madhra; INAMDAR MURAD ISMAIL
权利人:DAIICHI SANKYO CO LTD
摘要:The present invention relates to an improved and industrially advantageous process for the preparation of (1S, 4S, 5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one represented by the following formula (1) n n n n n n n n n n which is a key intermediate in the synthesis of edoxaban, a compound that exhibits on inhibitory effect on activated blood coagulation factor X (also referred to as activated factor X or FXa), and is useful as a preventive and/or therapeutic drug for thrombotic diseases. The process includes reacting (1S)-cyclohex-3-ene-1-carboxylic acid of formula (II) with a brominating agent selected from the group consisting of N-bromosuccinimide or 1,3-dibromo-5, 5-dimethylhydantoin in the presence of a base selected from calcium oxide or calcium hydroxide in a solvent selected from the group comprising of dicholoromethane, toluene, tetrahydrofuran, ethyl acetate, hexanes, cyclopentyl methyl ether (CPME) or a misture thereof to get (1S, 4S 5S)-4-bromo-6-oxabicyclo[3.2.1]octan-y-one of formula (1)

专利号:CN-116355876-A
优先权日:2023-03-06
标 题 :Recombinant esterase mutant, engineering bacterium and application thereof in synthesis of (S) -3-cyclohexene-1-formic acid

专利号:CN-116622672-A
优先权日:2023-04-27
标题 :Carboxylesterase mutant and application thereof in synthesis of (S) -3-cyclohexene-1-formic acid

专利号:CN-116622672-B
优先权日:2023-04-27
标题:Carboxylesterase mutant and application thereof in synthesis of (S) -3-cyclohexene-1-formic acid

专利号:CN-116396950-A
优先权日:2023-04-27
标 题:Carboxylesterase mutants and their application in the synthesis of (R)-3-cyclohexene-1-carboxylic acid

专利号:CN-115124418-A
优先权日:2021-03-26
标 题 :Synthesis method of (S) - (-) -3-cyclohexenecarboxylic acid