CAS: 516493-93-9; Azido-Peg5-Amine
该化合物是一种异乙基聚乙烯(PEG)衍生物,由一个端点形成一个亚齐德组,另一个端点形成一个主要矿泉,由5个单位的PEG空间仪分离.该化合物广泛用于生物合成和点击化学应用,原因是其双重反应性--Azide组参与的是紧张或铜催化的亚齐德-烷循环(SPAC/CuAAC),而该矿能够形成氨化联结或其他特定地雷的改变.PEG空间仪可以增强溶性,减少阻塞性,并提高生物兼容性.Azido-PEG5-胺在聚物合成,蛋白标签和聚合物化学方面特别宝贵,提供了受控的间隔和有效连接功能组之间.其稳定性和多功能性使得它成为先进的生物融合战略的首选.
相似化合物
951671-92-4 1207714-69-9 1333154-77-0物理性质
MSDS等安全信息
上下游产品
CAS号356046-26-9 Azido-PEG5-azide | CAS号2615-15-8 六乙二醇 | CAS号109789-40-4 Ms-PEG6-Ms | CAS号42749-27-9 Bis-Tos-PEG6 | CAS号352439-34-0 17-hydroxy-3,6,... | CAS号86770-69-6 叠氮-六聚乙二醇合成工艺路线路线简述
- 合成目标产物 17-Azido-3,6,9,12,15-Pentaoxaheptadecan-1-Amine 主要起始原料 3,6,9,12,15-Pentaoxaheptadecane-1,17-Diyl Bis-Azide
- (文献来源)合成步骤主要原料 3,6,9,12,15-Pentaoxaheptadecane-1,17-Diyl Bis-Azide
📜六甘醇置于4-二甲氨基吡啶,Sodium Azide,水,三乙胺,三苯基膦体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 13.0H,反应生成 17-叠氮-3,6,9,12,15-五氧杂十七烷-1-胺
参考文献:海洋天然产物 (-)-Dibromophakellstatin 环 C-官能化衍生物的合成和细胞毒性
标题:海洋天然产物 (-)-Dibromophakellstatin 环 C-官能化衍生物的合成和细胞毒性
摘要:对来自海绵 Phakellia Mauritiana 的细胞毒性海洋天然产物 (-)-Dibromophakellstatin 的环 C 功能化衍生物进行了构效关系研究.从羟基衍生物开始,通过转化为三氟甲磺酸酯,然后通过差向异构亲核取代进行醚化,实现了吡咯烷环的官能化.我们将 (12R)-Dibromo-12-Hydroxyphakellstatin 鉴定为最具细胞毒性的衍生物,其对一组十二个人类癌细胞系的平均 Ic50 值为 1.4 μm.然而,12S 非对映异构体是无活性的.dehydrophakellstatin 被合成为具有不饱和环 C 的 Phakellin 骨架的第一个例子.
DOI:10.1002/ejoc.201101175
海关参考信息
- 2905310000-1,2-乙二醇
2909110000-乙醚
2922110001-单乙醇胺
2909410000-二甘醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8247534-B2
优先权日:2006-12-13
标题 :Synthesis of radiofluorinated peptide using microwave activation technology
发明人：WILLIAMS LORENZO
权利人:WILLIAMS LORENZO; GE HEALTHCARE AS
摘要:The present invention addresses a novel method of preparing radiofluorinated peptide-based compounds and introducing those compounds into an automated radiosynthesis apparatus with the aid of microwave activation. The present invention further relates to obtaining radiopharmaceutical kits utilizing microwave activation technology for the preparation of obtaining peptide based compounds as well as a method for the use of preparing a peptide based compound.
专利号:US-8241606-B2
优先权日:2006-12-18
标题:Synthesis of a radiofluorinated peptide using photolabile protecting groups
发明人：WILLIAMS LORENZO
权利人:WILLIAMS LORENZO; GE HEALTHCARE AS
摘要:The present invention encompasses a method of preparing a radiofluorinated compound by adding a photolabile protecting group, R, to an aminoxy group of a peptide based compound wherein the peptide based compound reacts with a light of a specified wavelength in an automated radiosynthesis apparatus to form a radiofluorinated compound. The present invention further relates to a photolabile peptide based compound.
专利号:US-2010016551-A1
优先权日:2006-12-13
标 题:Synthesis of radiofluorinated peptide using microwave activation technology
专利号:EP-2099499-A2
优先权日:2006-12-13
标题:Synthesis of a radiofluorinated peptide using microwave activation technology
专利号:US-2010022746-A1
优先权日:2006-12-18
标 题 :Synthesis of a radiofluorinated peptide using photolabile protecting groups
专利号:EP-2125039-A2
优先权日:2006-12-18
标题 :Synthesis of a radiofluorinated peptide using photolabile protecting groups
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品牌试剂参考报价(招募中)
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主要参考文献
1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. doi: 10.1039/b811818c. Epub 2008 Sep 16.
合成参考文献
参考文献:10.1055/s-0041-1738560
摘要:Selective Modification of N-Terminal Cysteine Residues. Synfacts. 2022 Aug 18;18(09):1037. doi: 10.1055/s-0041-1738560.
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