CAS: 5096-57-1; (S)-Canadine
该化合物是天然产生的碱类,主要存在于各种植物物种中,特别是在帕帕韦罗塞亚家族中,其特点是结构框架,包括一个苯基,该化合物具有一系列生物活动,包括止痛剂和抗炎特性,这使它对药物学研究感兴趣.加那迪因一般是黄色晶状固体,在有机溶剂中可溶解,但水中的溶解性有限.该化合物的药用植物和作用机制仍在调查之中,但据信与各种...
- 英文名称(S)-Canadine
- 中文名称四氢小檗碱
- 其它别名13aa-Berbine,9,10-dimethoxy-2,3-(methylenedioxy)- (8CI); 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine,5,8,13,13a-tetrahydro-9,10-dimethoxy-, (S)-; Canadine (6CI,7CI); (-)-Canadine; (-)-Tetrahydroberberine; (-)-a-Canadine; (S)-(-)-7,8,13,13a-Tetrahydroberberine; (S)-(-)-Canadine; (S)-(-)-Tetrahydroberberine; (S)-Canadine; 9,10-Dimethoxy-2,3-(methylenedioxy)-13aa-berbine; l-Canadine; a-Canadine
- CAS编号5096-57-1
- MFCD编号:MFCD00067284
- EINECS号:225-815-0
- FDA UNII编号:Q97V5BUT9D
- 分子式:C20H21NO4分子量:339.391
- 产品CID: 1498206
- 产品分类天然产物 → 生物碱
物理性质
上下游产品
canadine (S)-9,10-Dimethoxy-13-p-tolylsulfanyl-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline (-)-canadine HCl berberine chloride12,13-dihydr°Chelerythrine berberine iodide all°Cryptopine 7,8-dihydroberberine合成工艺路线路线简述
📜(8S,14S)-(-)-8-Cyanocanadine置于sodium Tetrahydroborate,三氟乙酸体系中,化学反应生成 坎那定; 氢化小蘖碱
参考文献:小b碱n-氧化物的polonovski-Potier反应.8-羟甲基和8-甲基berbines的合成
标题:小b碱n-氧化物的polonovski-Potier反应.8-羟甲基和8-甲基berbines的合成
摘要:的polonovski-博天反应反式和顺berbines ñ-Oxides进行了研究.由反式n-氧化物获得的8-氰基衍生物用于合成8-羟甲基和8-甲基小碱.将该方法应用于从(14 S)-(-)-犬精的立体控制合成(8 R,14 S)-(-)-8-甲基犬精.
DOI:10.1016/s0040-4020(00)00945-5
海关参考信息
- 2902600000-乙苯
2905110000-甲醇
2907210001-间苯二酚
2907121100-间甲酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10793885-B2
优先权日:2013-08-16
标 题 :Compositions and methods for making noscapine and synthesis intermediates thereof
发明人：FACCHINI PETER JAMES; CHEN XUE; DANG THI THU THUY
权利人:WILLOW BIOSCIENCES INC
摘要:Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.
专利号:EP-3137618-A1
优先权日:2014-04-29
标 题 :Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds
专利号:WO-2015164960-A1
优先权日:2014-04-29
标 题:Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1021/np980471n
摘要:Chen IS, Chen TL, Chang YL, Teng CM, Lin WY. Chemical constituents and biological activities of the fruit of Zanthoxylum integrifoliolum. J Nat Prod. 1999 Jun;62(6):833–7. doi: 10.1021/np980471n.
参考文献:10.1021/tx050356u
摘要:Inbaraj JJ, Kukielczak BM, Bilski P, He YY, Sik RH, Chignell CF. Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine. Chem Res Toxicol. 2006 Jun;19(6):739–44. doi: 10.1021/tx050356u.
参考文献:10.1248/bpb.27.1270
摘要:Saito S, Tanaka M, Matsunaga K, Li Y, Ohizumi Y. The Combination of Rat Mast Cell and Rabbit Aortic Smooth Muscle Is the Simple Bioassay for the Screening of Anti-allergic Ingreditent from Methanolic Extract of Corydalis Tuber. Biological & Pharmaceutical Bulletin. 2004;27(8):1270–4. doi: 10.1248/bpb.27.1270.
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