CAS: 4593-90-2; 3-Phenylbutyric Acid

该化合物是一种有机化合物,其分子式为C10H12O2, 其组成为与丁酸乙碳相连的一个苯基组,这种白色晶状固体在水中可轻量溶解,但很容易溶解于有机溶剂中,在制药和精细化学合成中,特别是在生产非类反炎药物(NSAIDs)和其他生物活性化合物方面,它是一个多用途中间体,其代用苯结构加强了对烷基和凝聚反应的再活性.该化合物因其稳定性,一致性和可预测的再活性而得到重视,因此适合研究和工业应用,需要精确的芳香碳酸衍生物.

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相似化合物

772-14-5 53086-49-0 53086-50-3

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CAS号201230-82-2 carbon monoxide | CAS号98-83-9 α-甲基苯乙烯 | CAS号108-86-1 溴苯 | CAS号107-93-7 巴豆酸 | CAS号16251-77-7 β-甲基苯丙醛 | CAS号104602-93-9 1,1,1-trichloro... | CAS号704-79-0 3-phenylbut-2-e... | CAS号591-51-5 苯基锂 | CAS号1134-71-0 (S)-(+)-3-pheny... | CAS号6072-57-7 3-甲基-1-茚酮 | CAS号1004-63-3 (1S)-1-methyl-1... | CAS号3461-39-0 methyl-3-phenyl... | CAS号36318-77-1 [1-(dichloromet... | CAS号1533-20-6 1,3-联苯基-1-丁酮 | CAS号18435-75-1 2H-1-Benzopyran... | CAS号17913-10-9 4-phenylpentan-2-one | CAS号767-59-9 1-甲基茚 | CAS号772-14-5 (R)-3-苯基丁酸 | CAS号4593-90-2 3-苯基丁酸

合成工艺路线路线简述

    📜亚苯甲基丙二酸二乙酯置于氢氧化钾体系中,化学反应生成 (+/-)-3-苯基丁酸
    参考文献:Kohler,American Chemical Journal,1905,Vol. 34,P. 145
    标题:Kohler,American Chemical Journal,1905,Vol. 34,P. 145

    海关参考信息

    专利信息


    专利号:US-9045381-B2
    优先权日:2010-10-19
    标 题:Ruthenium complexes and their uses in processes for formation and/or hydrogenation of esters, amides and derivatives thereof
    发明人:MILSTEIN DAVID; BALARAMAN EKAMBARAM; GUNANATHAN CHIDAMBARAM; GNANAPRAKASAM BOOPATHY; ZHANG JING
    权利人:MILSTEIN DAVID; BALARAMAN EKAMBARAM; GUNANATHAN CHIDAMBARAM; GNANAPRAKASAM BOOPATHY; ZHANG JING; YEDA RES & DEV
    摘要:The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.

    专利号:US-6372938-B1
    优先权日:2001-05-21
    标题:Synthesis of 4-phenylbutyric acid
    发明人:BURZYNSKI STANISLAW R; MUSIAL LESZEK
    权利人:BURZYNSKI STANISLAW R
    摘要:A method of synthesizing compounds of Formula I:by reacting aromatic compounds with butyrolactone, followed by neutralization with base. The reaction can be conducted in the presence of a catalyst. Preferred catalysts are Lewis acids. A preferred product of Formula I is 4-phenylbutyric acid, which is obtained by the reaction of benzene with butyrolactone in the presence of aluminum chloride, followed by neutralization with base.

    专利号:US-6664282-B2
    优先权日:1999-09-17
    标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
    发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
    权利人:TORREY PINES INST
    摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

    专利号:US-6268535-B1
    优先权日:1998-01-09
    标题 :Synthesis of 3-aryl-1-indanamines
    发明人:MOUSSA ADEL M; HAIDER REEM; TAFT HEATHER; JURAYJ JURJUS; WANG WEIHENG; SUH HAESUK
    权利人:PHARM ECO LAB INC
    摘要:The present invention is a method of preparing a 3-aryl-1-indanamine represented by structural formula I:and physiologically acceptable salts thereof.In structure I, phenyl ring A can be unsubstituted or substituted with 1-4 substitutents.R1 is an aromatic group which can be substituted or unsubstituted.R2 and R3 are each, independently, hydrogen, an aliphantic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, an aralkyl group, or a substituted aralkyl group. Alternatively, R2 and R3, taken together with the nitrogen substitutent on the indan ring, form a non-aromatic ring system having 1-2 heteroatoms.

    专利号:US-2007225490-A1
    优先权日:2003-12-15
    标 题:Cationic Oligomer of a Saccharide for Resolving Enantiomers and Asymmetric Synthesis
    发明人:CHING CHI B; YOUNG DAVID J; MUDERAWAN I WAYAN; ONG TENG T; NG SIU C
    权利人:SELEX SENSORS & AIRBORNE SYS
    摘要:A cationic oligomer of a saccharide, wherein the saccharide is functionalized by a cationic group, for example an ammonium, phosphonium, imidazolium, or pyridinium group. In a preferred embodiment, the cationic oligomer of a saccharide is a cationic cyclodextrin. There is also provided a use of the cationic oligomer of a saccharide as a chiral agent for resolving enantiomers by a chromatographic method or an asymmetric synthesis.

    专利号:US-5856107-A
    优先权日:1997-02-04
    标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
    发明人:OSTRESH JOHN M; HOUGHTEN RICHARD A
    权利人:TREGA BIOSCIENCES INC
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Sariaslani Fs, Et Al. Degradation Of 3-Phenylbutyric Acid By Pseudomonas Sp. J Bacteriol. 1982 Oct;152(1):411-21.
    [参考文献]: Simoni S, Et Al. Enantioselective Metabolism Of Chiral 3-Phenylbutyric Acid, An Intermediate Of Linear Alkylbenzene Degradation, By Rhodococcus Rhodochrous Pb1. Appl Environ Microbiol. 1996 Mar;62(3):749-55.
    [参考文献]: A A Van Landeghem, Et Al. Adsorption Of Small Hydroxy Acids On Glass: A Pitfall In Quantitative Urinary Organic Acid Analysis By Gc-Ms. J Inherit Metab Dis. 1999 May;22(3):293-6.
    [参考文献]: Eva Bandres, Et Al. Epigenetic Regulation Of Microrna Expression In Colorectal Cancer. Int J Cancer. 2009 Dec 1;125(11):2737-43.
    [参考文献]: Helge Jochens, Et Al. Natural Diversity To Guide Focused Directed Evolution. Chembiochem. 2010 Sep 3;11(13):1861-6.

    合成参考文献


    摘要:Merino, P., Science of Synthesis, (2010) 45, 289.
    摘要:Parmeggiani, F.; Galman, J. L.; Montgomery, S. L.; Turner, N. J., Science of Synthesis, (2019) , 398.
    摘要:HANSCH,C ET AL. (1995)
    摘要:R. F. R. Church and M. J. Weiss, J. Org. Chem. 35, 2465 (1970).
    摘要:Sawamura, M.; Shimizu, Y., Science of Synthesis: Knowledge Updates, (2024) 2, 235.
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