CAS: 4264-83-9; 4-Nitrophenyl Phosphate Disodium Salt

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CAS号4043-96-3 对硝基酚磷酸钠 | CAS号14609-74-6 Phenol, 4-nitro...

专利信息

专利号:US-11649285-B2
优先权日:2016-08-03
标题 :Identification of VSIG3/VISTA as a novel immune checkpoint and use thereof for immunotherapy
发明人：KALABOKIS VASSILIOS; WANG JINGHUA; WU GUOPING; BAZAN JOSE FERNANDO; VALLEY CHRISTOPHER CARLIN
权利人:BIO TECHNE CORP
摘要:The ligand for VISTA is identified (VSIG3) as well as the use of this ligand and receptor interaction in the identification or synthesis of a VSIG3 agonist or antagonist compounds, preferably antibodies, polypeptides and fusion proteins which agonize or antagonize the effects of VSIG3 and/or VISTA and/or the VSIG3/VISTA interaction. These antagonists may be used to suppress VSIG3/VISTA's suppressive effects on T cell immunity, and more particularly used in the treatment of cancer, or infectious disease. These agonist compounds may be used to potentiate or enhance VSIG3/VISTA's suppressive effects on T cell immunity and thereby suppress T cell immunity, such as in the treatment of autoimmunity, allergy or inflammatory conditions. Screening assays for identifying these agonists and antagonist compounds are also provided.

专利号:US-5989819-A
优先权日:1995-05-26
标 题 :Method for quantitatively determining an antibody having the ability to inhibit the activity of a reverse transcriptase
发明人：ODAWARA FUMITOMO
权利人:ASAHI CHEMICAL IND
摘要:PCT No. PCT/JP96/01407 Sec. 371 Date Nov. 18, 1997 Sec. 102(e) Date Nov. 18, 1997 PCT Filed May 24, 1996 PCT Pub. No. WO96/37781 PCT Pub. Date Nov. 28, 1996Disclosed is a method for quantitatively determining an antibody, contained in a biological sample, having the ability to inhibit the activity of a reverse transcriptase derived from an HIV, comprising: reacting a hybridization product, immobilized on a solid phase, of a primer consisting essentially of oligodeoxythymine nucleotide and an RNA template consisting essentially of adenine ribopolynucleotide with a reverse transcriptase derived from HIV, to thereby bind the reverse transcriptase to the hybridization product; conducting a synthesis of a DNA complementary to the RNA template from a deoxymononucleotide triphosphate in the presence of the reverse transcriptase activity-inhibiting antibody; and measuring the amount of the synthesized DNA and quantitatively determining the above-mentioned antibody, based on the measured amount of the synthesized DNA. The method of the present invention can be performed with ease and with high reproducibility in classifying and quantitatively determining the antibodies against the epitopes of a viral reverse transcriptase. By the method of the present invention, not only the virus having mutated during a latent period thereof, and the properties which the virulis exhibits as a result of the mutation, but also a virus having acquired drug resistance as a result of the administration of the drugs to the host, can be studied by quantitatively determining the antibodies. Further, it has also become possible to accurately and promptly determine the changes in the infected host, such as the change in the ability to produce antibodies, which occur in accordance with the progression of illness.

专利号:WO-2023033664-A1
优先权日:2021-09-04
标题:Cd44 glycoepitopes and chimeric vaccine glycoconjugates for cancer therapy and synthesis methods thereof
发明人：RIBEIRO DE CASTRO FERREIRA JOSÉ ALEXANDRE; MOREIRA NETO DA SILVA ANDRÉ; NEVES FREITAS RUI FILIPE; DE LARA SANTOS LÚCIO JOSÉ; RELVAS DOS SANTOS MARTA FILIPA; MILHAZES GAITEIRO CRISTIANA; FERREIRA PEIXOTO ANDREIA FILIPA; LINHARES MIRANDA ANDREIA RAFAELA; GOMES FERREIRA DYLAN; TEIXEIRA DE CASTRO FLà VIA RAQUEL; CARMELINO CARDOSO SARMENTO BRUNO FILIPE; CARDOSO OLIVEIRA MARIA JOSÉ
权利人:I3S INSTITUTO DE INVESTIG E INOVACAO EM SAUDE ASSOCIACAO; INST PORTUGUES DE ONCOLOGIA DO PORTO FRANCISCO GENTIL EPE; REQUIMTE REDE DE QUIM E DE TECNOLOGIA ASSOCIACAO
摘要:The present invention refers to glycopeptides derived from the short CD44 isoforms lacking the amino acids encoded by exons 6-14, the said glycopeptides presenting at least one or multiple serine or threonine residues substituted with Tn ( GalNAca-O-Ser/Thr ) and/or sialyl-Tn (STn; Neu5Aca2-6GalNAca-O-Ser/Thr) antigens. The present invention further provides a method for synthesizing the herein disclosed glycopeptides, the said method comprising a one-pot glycosylation of synthetic short isoform CD44 peptides through combination with nucleotide sugars and glycosyl trans f erases and subsequent purification of the CD44s-Tn glycopeptides by lectin affinity chromatography followed by Ti02 chromatography or liquid chromatography. In one embodiment, the present invention further comprises immunogenic chimeras derived from the said CD44-Tn and/or STn glycopeptides, which are linked, in a polyvalent form, to a carrier immunogenic protein, such as keyhole limpet hemocyanin (KLH) or cross-reacting material (CRM197). Methods for conj ugating the synthesized CD44s-Tn glycopeptides to the immunogenic protein carriers CRM197 and KLH, are described, generating the chimeric glycopeptides, herein termed CRM197 -CD44 s-Tn and KLH-CD44s-Tn, respectively. The present invention further regards the above-mentioned CD44-Tn/STn glycopeptides or compositions comprising said glycopeptides for use in the treatment of cancer and pre-neoplastic diseases, most preferably of neoplastic diseases expressing short CD44 isoforms, through generation of antibodies against cancer cells and treatment and prevention of cancer by vaccination. The glycopeptides, compositions, synthesis methods and uses of the present invention can be advantageously employed in the treatment of cancer, alone or in combination with immune checkpoint inhibitor therapy, chemotherapy, and radiotherapy.

专利号:WO-0110870-A1
优先权日:1999-08-10
标题:Transition metal complexes of n,n',n'-trialkyl- cis,cis-1,3,5-triaminocyclohexane and related compositions and methods of synthesis and use
发明人：BRECHBIEL MARTIN; PLANALP ROY P; DEAL KIM
权利人:US HEALTH; BRECHBIEL MARTIN; PLANALP ROY P; DEAL KIM
摘要:The present invention provides transition metal complexes of N,N',N'-trialkyl-cis,cis-1,3,5-triaminocyclohexane and related compositions and methods of synthesis and use in vitro and in vivo, such as a therapeutic agent or a delivery/imaging agent.

专利号:US-6765104-B1
优先权日:1999-08-10
标题 :Transition metal complexes of n, n',n″trialkyl-cis-1,3,5-triaminocyclohexane and related compositions and methods of synthesis and use
发明人：BRECHBIEL MARTIN; PLANALP ROY P; DEAL KIM
权利人:US HEALTH
摘要:The present invention provides transition metal complexes of N,N′,N″-trialkyl-cis,cis-1,3,5-triaminocyclohexane and related compositions and methods of synthesis and use in vitro and in vivo, such as a therapeutic agent or a delivery/imaging agent.

专利号:EP-0658564-B1
优先权日:1986-04-30
标题 :Electroluminescent compounds and intermediates in their synthesis
发明人：MASSEY RICHARD J; POWELL MICHAEL J; MIED PAUL A; POONIAN MOHINDAR S; FENG PETER; CIANA LEOPOLDO DELLA; DRESSICK WALTER J
权利人:IGEN INT INC
摘要:Novel compounds for use in electrochemiluminescent assays and characterised by containing the structure        X - Y - ZwhereinX represents one or more nucleotides which may be the same or different, one or more amino acids which may be the same or different, an antibody, an analyte of interest or an analogue of an analyte of interestY represents a linker group attached to X and Z,andZ represents an electrochemiluminescent moiety, and intermediates employed in their synthesis.