专利号:US-7279572-B2 优先权日:2003-05-22 标题:Process for the 2-stage synthesis of hexanitrohexaazaisowurtzitane starting from a primary amine 发明人:CAGNON GUY; ECK GENEVIEVE; HERVE GREGOIRE; JACOB GUY 权利人:SNPE MATERIAUX ENERGETIQUES 摘要:A subject-matter of the present invention is a novel process for the synthesis of hexanitrohexaazaisowurtzitane (HNIW), a compound of use as energetic filler in powders, propellants and explosives. n This process comprises a first stage of reaction of an α,β-dicarbonyl derivative with a primary amine which makes it possible to form a hexasubstituted hexaazaisowurtzitane derivative. n The HNIW is subsequently obtained directly, in a single reaction stage, by nitration of the hexasubstituted hexaazaisowurtzitane derivative. n This process, in only 2 stages starting from a primary amine, is particularly simple and inexpensive.
专利号:US-7173059-B2 优先权日:2003-05-08 标题:Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same 发明人:ALBIZATI KIM FRANCIS; BABU SRINIVASAN 权利人:AGOURON PHARMA 摘要:Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed.
专利号:US-2013338369-A1 优先权日:2011-03-07 标 题 :Process for the Synthesis of Aminobiphenylene 发明人:HEINRICH MARKUS; PRATSCH GERALD 权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE 摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
专利号:US-6472534-B2 优先权日:1999-10-21 标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors 发明人:BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K 权利人:AGOURON PHARMA 摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
专利号:US-6765117-B2 优先权日:1997-10-24 标题:Process for stereoselective synthesis of prostacyclin derivatives 发明人:MORIARTY ROBERT M; PENMASTA RAJU; GUO LIANG; RAO MUNAGALA S; STASZEWSKI JAMES P 权利人:UNITED THERAPEUTIC CORP 摘要:An improved method is described for making 9-deoxy-PGF 1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deoxy-PGF 1 -type compounds.
专利号:US-4894385-A 优先权日:1985-01-16 标 题:Imidazole derivatives as inhibitors of TXA2 synthesis 发明人:KAWAMOTO ISAO; ENDO ROKURO; MATSUDA KEIICHI; USHIYAMA SHIGERU; OSHIMA TAKESHI 权利人:SANKYO CO 摘要:Compounds of formula (I): ##STR1## (wherein n is 0, 1 or 2 and R 1 , R 2 , R 4 , R 5 , R 6 , X, Y and Z are a variety of groups and atoms) have the ability to inhibit the synthesis of thromboxane A 2 and hence are useful in the treatment or prophylaxis of thrombotic conditions.
[参考文献]: Audrey R Smith, Et Al. Absolute Photoionization Cross Sections Of Furanic Fuels: 2-Ethylfuran, 2-Acetylfuran And Furfural. J Mass Spectrom. 2015 Nov;50(11):1206-13. [参考文献]: Koji Noge, Et Al. Defensive Roles Of (E)-2-Alkenals And Related Compounds In Heteroptera. J Chem Ecol. 2012 Aug;38(8):1050-6. [参考文献]: Nadhem Aissani, Et Al. Nematicidal Activity Of The Volatilome Of Eruca Sativa On Meloidogyne Incognita. J Agric Food Chem. 2015 Jul 15;63(27):6120-5.
合成参考文献
摘要:Hou, X.-L.; Peng, X.-S.; Yeung, K.-S.; Wong, H. N. C., Science of Synthesis Knowledge Updates, (2011) 2, 342. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 89. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 50. 摘要:Xia, J.-B.; You, S.-L., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 122. 摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 343.