CAS: 21190-87-4; 6-Bromo-2-Pyridinecarboxylic Acid

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122918-25-6 21190-88-5 26218-75-7

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CAS号5315-25-3 2-溴-6-甲基吡啶 | CAS号26218-75-7 6-溴吡啶-2-甲酸甲酯 | CAS号166953-27-1 methyl 3-(6-bro... | CAS号626-05-1 2,6-二溴吡啶 | CAS号1824-81-3 2-氨基-6-甲基吡啶 | CAS号124-38-9 二氧化碳 | CAS号1061750-15-9 6-(4-吗啉)-2-吡啶羧酸乙酯 | CAS号33674-96-3 6-溴-2-羟甲基吡啶 | CAS号34160-40-2 6-溴吡啶-2-甲醛 | CAS号337535-94-1 6-溴-N-甲基吡啶甲酰胺 | CAS号39774-28-2 6-苯基吡啶-2-羧酸 | CAS号344331-90-4 6-溴-2-叔丁氧羰基氨基吡啶 | CAS号153435-70-2 6-bromo-N,N-dim... | CAS号36052-26-3 6-氨基吡啶甲酸甲酯 | CAS号122918-25-6 6-溴-2-氰基吡啶 | CAS号329946-26-1 6-bromo-N-metho...

2-溴-6-甲基吡啶置于potassium Permanganate体系中,用 水 用作溶剂,以75%的收率获得6-溴-2-吡啶羧酸
参考文献:以 1-Hydoroxy-2(1H)-吡啶酮 (Hopo) 作为螯合单元的新型四齿螯合剂的合成:与 Fe (III) 的相互作用,溶液热力学和 Dft 研究
标题:以 1-Hydoroxy-2(1H)-吡啶酮 (Hopo) 作为螯合单元的新型四齿螯合剂的合成:与 Fe (III) 的相互作用,溶液热力学和 Dft 研究
摘要:摘要 1,2-羟基吡啶酮 (1,2-Hopo) 形成非常稳定的过渡金属配合物,可能有多种用途,其中铁配合物长期以来一直用于治疗铁过载疾病,如 β-地中海贫血.一种新的四齿螯合剂,1-羟基-N-[3-[2-[2-[3-[(1-羟基-6-氧代-吡啶-2羰基)氨基]丙氧基]乙氧基]乙氧基]丙基]-6-合成了具有两个具有长链胺主链的 1,2-Hopo 单元的氧代-吡啶-2-甲酰胺 (L),并通过各种技术进行了表征,例如 Tlc,溶解度,熔点,Ft-Ir,1H NMR,13C NMR,Esi-Ms,Uv-Vis 和发射光谱.配体的质子化常数通过电位法和分光光度法在 25°+/-1oc 的水性介质中测定.还研究了配体及其 Fe(III) 配合物在水溶液中的溶液热力学.发现配体的 Pka 值为 7.34 和 6.06,发现金属配合物 (M2L3) 的形成常数为 Logβ230 = 42.45.为了支持实验数据,Dft
Doi:10.1016/j.Molstruc.2020.128796

专利信息

专利号:US-10633365-B2
优先权日:2016-04-29
标题 :Synthesis of indazoles
发明人：THALER TOBIAS; PLATZEK JOHANNES; GUIMOND NICOLAS
权利人:Bayer Pharma AG
摘要:The present invention relates to a novel method of preparing a 2-substituted indazole of formula (I) to novel intermediate compounds, and to the use of intermediate compounds for the preparation of said 2-substituted indazole.

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:WO-2017186693-A1
优先权日:2016-04-29
标题 :Synthesis of indazoles

专利号:WO-2017186689-A1
优先权日:2016-04-29
标 题 :Synthesis of indazoles

专利号:CN-109071489-A
优先权日:2016-04-29
标 题:Synthesis of indazole

专利号:CN-109071489-B
优先权日:2016-04-29
标题 :Synthesis of Indazole