CAS: 2022-78-8; 5-Fluoropyrimidin-2(1H)-One

相似化合物

557-01-7 38353-09-2 79387-69-2

上下游产品

4-thio-5-fluorouracil Flucytosine 1-(4-Chlorobenzyloxy)methyl-5-fluoropyrimidin-2-one 1-Propargyl-5-fluor-pyrimid-2-on

氟胞嘧啶置于bifidobacterium Longum Cytosine Deaminase体系中,用 Various Solvent(S) 用作溶剂,化学反应生成2-羟基-5-氟嘧啶
参考文献:Cloned Cytosine Deaminase Gene Expression Ofbifidobacterium Longumand Application To Enzyme/pro-Drug Therapy Of Hypoxic Solid Tumors
标题:Cloned Cytosine Deaminase Gene Expression Ofbifidobacterium Longumand Application To Enzyme/pro-Drug Therapy Of Hypoxic Solid Tumors
摘要:长双歧杆菌是正常菌群中的一种非致病性厌氧细菌.最近,有报道称长双歧杆菌在缺氧实体瘤中积累.目的基因在实体瘤中通过穿梭载体 Pbles100 转染的长双歧杆菌中表达.在本报告中,我们构建了 Pbles100-S-Ecd,其中包含胞嘧啶脱氨酶基因.我们通过蛋白质印迹证实转染的长双歧杆菌产生胞嘧啶脱氨酶.此外,转染的长双歧杆菌产生胞嘧啶脱氨酶,将 5-氟胞嘧啶转化为 5-氟尿嘧啶.长双歧杆菌可用于缺氧实体瘤的酶/前药治疗.
Doi:10.1271/bbb.66.2362

专利信息

专利号:US-11306041-B2
优先权日:2017-03-30
标 题:Catalytic synthesis of super linear alkenyl arenes using rhodium catalysts
发明人：SCHINSKI WILLIAM; GOLDMAN ALAN; GUNNOE THOMAS B; WEBSTER-GARDINER MICHAEL S; SCHWARTZ NICHOLE
权利人:UNIV VIRGINIA PATENT FOUNDATION
摘要:Catalytic methods for synthesis of super linear alkenyl arenes and alkyl arenes are provided. The methods are capable of synthesizing super linear alkyl and alkenyl arenes from simple arene and olefin starting materials and with high selectivity for linear coupling. Methods are also provided for making a 2,6-dimethylnapthalene (DMN) or 2,6-methylethylnapthalene (MEN).

专利号:WO-0231176-A1
优先权日:2000-10-12
标题:Process for producing nucleoside
发明人：FUJIWARA JUNYA; KOMATSU HIRONORI; AWANO HIROKAZU; FUKAZAWA NOBUYUKI; ANDO TOMOYUKI; TSUCHIYA KATSUTOSHI; CHIBA KYOKO; UMETANI HIDEKI; ARAKI TADASHI; YAMAUCHI TAKAHIRO
权利人:MITSUI CHEMICALS INC; FUJIWARA JUNYA; KOMATSU HIRONORI; AWANO HIROKAZU; FUKAZAWA NOBUYUKI; ANDO TOMOYUKI; TSUCHIYA KATSUTOSHI; CHIBA KYOKO; UMETANI HIDEKI; ARAKI TADASHI; YAMAUCHI TAKAHIRO
摘要:An anomer mixture of a nonnatural 1-phosphorylated saccharide is reacted with a base by the action of phosphorylase activity, wherein the exchange reaction between the phosphate group of the 1-phosphorylated saccharide and the base is conducted anomer-selectively. Metal cations capable of forming a sparingly water-soluble salt with phosphate ions are caused to be present in the reaction mixture, whereby the phosphate ions which are a by-product of the reaction can be precipitated as a sparingly water-soluble salt and the reaction equilibrium can be shifted toward nucleoside synthesis. Thus, the yield of the target compound is heightened. By utilizing a difference in the rate of the exchange reaction, a mixture of optical isomers of the nucleoside can be obtained in which one of the isomers is contained in a higher proportion.

专利号:EP-1179598-B1
优先权日:1999-05-13
标题 :Process for producing nucleoside compound
发明人：NIKUMARU SEIYA; NAKAMURA TAKESHI
权利人:MITSUI CHEMICALS INC
摘要:In preparation of a nucleoside compound by reacting a pentose-1-phosphate and a nucleic acid base or its analogue in the presence of enzyme activity of nucleoside phosphorylase, a metal salt capable of forming a water-insoluble salt with phosphoric acid may be added to a reaction system to eliminate phosphoric acid, a byproduct, from the reaction system so that the equilibrium reaction can be shifted toward a direction for nucleoside synthesis, leading to an improved yield of the desired nucleoside compound.