CAS: 1746-28-7; 1-Bromo-4-(2-Bromoethyl)Benzene

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CAS号1878-68-8 对溴苯乙酸 | CAS号4654-39-1 4-溴苯乙醇 | CAS号99-73-0 对-α-二溴苯乙酮 | CAS号16532-79-9 对溴苯乙腈 | CAS号589-15-1 对溴溴苄 | CAS号106-37-6 对二溴苯 | CAS号15221-61-1 2-(4-溴苯基)-N,N-二甲基乙胺 | CAS号23703-22-2 1-溴-4-己苯 | CAS号57775-08-3 3-(4-溴苯基)丙腈 | CAS号736991-39-2 4-(4-溴苯乙基)吗啉 | CAS号106418-67-1 1-溴4-癸基苯 | CAS号14310-24-8 4-Bromobibenzyl | CAS号711018-68-7 2-(4-bromopheny... | CAS号65984-53-4 3-(4-溴苯基)丙-1-胺

📜4-溴苯乙醇置于三乙胺,Lithium Bromide体系中,用 二氯甲烷,丙酮 用作溶剂,化学反应 0.75H,反应生成4-溴苯乙基溴
参考文献:对映选择性铜(i)/手性磷酸催化烯丙基和苄基ch键的分子内胺化.
标题:对映选择性铜(i)/手性磷酸催化烯丙基和苄基ch键的分子内胺化.
摘要:通过氢原子转移(hat)过程进行的涉及自由基的对映选择性氧化ch键功能化已成为一种获得功能多样化对映体富集产物的有前途的方法,而不对称c(sp3)-H键胺化仍然是一个艰巨的挑战.为了解决该问题,本文描述了一种双cui /手性磷酸(cpa)催化体系,其用于自由基参与的对映选择性分子内c(sp3)-H胺化,其不仅具有烯丙基位置,而且具有宽的底物范围,也具有苄基位置.使用4-甲氧基-Nhpi(nhpi = N-羟基邻苯二甲酰亚胺)作为稳定的和化学选择性的hat介体前体对于完成此转化至关重要.初期机理研究表明,涉及到由hat过程产生的关键的烯丙基或苄基自由基中间体.
Doi:10.1002/anie.201911742

专利信息

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:US-6426421-B1
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries

专利号:US-5494918-A
优先权日:1991-03-08
标题 :Multicyclic tertiary amine polyaromatic squalene syntase inhibitors
发明人：NEUENSCHWANDER KENT; AMIN DILIP; SCOTESE ANTHONY C; MORRIS ROBERT L
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

专利号:WO-9215579-A1
优先权日:1991-03-08
标 题 :Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
发明人：NEUENSCHWANDER KENT; AMIN DILIP; SCOTESE ANTHONY C; MORRIS ROBERT L
权利人:RHONE POULENC RORER INT
摘要:This invention relates to polycyclic compounds containing two mono and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.