CAS: 16400-50-3; 3,3',5,5'-Tetrabromo-1,1'-Biphenyl

该化合物是一种多溴联苯化合物,其特征是联苯结构中含有4个溴原子,该化合物是被称为溴化阻燃剂的更大类别化学品的一部分,用于减少各种材料中的易燃性;其分子结构由两个由单一联结连接的苯环组成,溴代二苯的替代品位于3,3',5,5'-四溴联苯的方位;多溴原子的存在极大地改变了联苯骨的物理和化学特性,增强了其热稳定性和疏水性;3,3',5,5'-四溴联苯在室温度下一般是固态的,在水中是溶解的,但在有机溶剂中是溶解的;由于其潜在的环境持久性和生物累积性,它引起了人们对其生态影响和人类健康影响的关切,导致不同管辖区的监管审查;因此,其使用受到许多应用的限制或逐步停止.

结构式图片

相似化合物

16372-96-6 2113-57-7 16400-51-4

欧盟法规

[ECHA物质

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合成工艺路线路线简述

    📜4,4'-二氨基-3,3',5,5'-四溴联苯置于硫酸体系中,化学反应生成3,3',5,5'-四溴-1,1'-联苯
    参考文献:Van Roosmalen,Recueil Des Travaux Chimiques Des Pays-Bas,1934,Vol. 53,P. 359,362
    标题:Van Roosmalen,Recueil Des Travaux Chimiques Des Pays-Bas,1934,Vol. 53,P. 359,362

    专利信息


    专利号:US-5877214-A
    优先权日:1996-09-12
    标题:Polyaryl-poly(ethylene glycol) supports for solution-phase combinatorial synthesis
    发明人:KIM RONALD M
    权利人:MERCK & CO INC
    摘要:The present invention is directed to the certain polyaryl-poly(ethylene glycol) compounds ('polyaryl-PEG' compounds) which are useful as soluble polyvalent supports in the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery process or in developing compounds with desired physical and chemical properties.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:L628: ATSDR - Agency for Toxic Substances and Disease Registry (2004). Toxicological profile for polybrominated biphenyls and polybrominated diphenyl ethers (PBBs and PBDEs). U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
    摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
    摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
    摘要:L629: Wikipedia. Polybrominated biphenyl. Last Updated 9 June 2009. http://en.wikipedia.org/wiki/Polybrominated_biphenyls
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