CAS: 163438-09-3; (R)-1-(Tert-Butoxycarbonyl)Piperidine-3-Carboxylic Acid

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84358-12-3 88495-54-9 193693-67-3

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号498-95-3 3-哌啶甲酸 | CAS号86447-11-2 1-B°C-1,2,5,6-四... | CAS号194726-40-4 (R)-1-叔丁氧羰基-3-哌啶甲酸乙酯 | CAS号300-08-3 氢溴酸槟榔碱 | CAS号495-19-2 1,2,5,6-四氢吡啶-3-羧酸甲酯 | CAS号6027-92-5 Guvacine hydrob... | CAS号891494-63-6 6-溴-3-(1-甲基-1H-... | CAS号1234709-86-4 (S)-2-(N-B°C-哌啶... | CAS号1013937-63-7 VTP-27999 2,2,2... | CAS号884510-86-5 (3R)-3-[(甲氧基甲基氨... | CAS号934423-10-6 (R)-N-B°C-哌啶-3-羧酸甲酯 | CAS号942142-79-2 tert-butyl (3R)...

氢溴酸槟榔碱置于甲醇,C56H72Irnop(1+)*c32H12Bf24(1-),水,氢溴酸,氢气,Potassium Carbonate,Caesium Carbonate,Sodium Hydroxide体系中,用 甲醇,水,1,2-二氯乙烷,叔丁醇 用作溶剂,60.0 °C,607.99 Kpa 条件下,反应 19.17H,反应生成N-Boc-(R)-3-甲酸哌啶
参考文献:铱催化不饱和杂环酸的对映选择性加氢
标题:铱催化不饱和杂环酸的对映选择性加氢
摘要:螺旋结合:一种高度对映选择性的不饱和杂环羧酸的加氢已经通过使用手性铱/ Spirophosphino恶唑啉催化剂开发(参见方案; Bar ˚f-=四[3,5-双(三氟甲基)苯基]硼酸盐,的boc =叔丁氧羰基) .该反应提供了制备具有优异对映选择性的旋光杂环酸的有效方法.
Doi:10.1002/anie.201301341

专利信息

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-6872716-B2
优先权日:2000-09-11
标题:Antipsychotic sulfonamide-heterocycles, and methods of use thereof
发明人：WU XINHE; AQUILA BRIAN M; SHAO LIMING; RADEKE HEIKE; CUNY GREGORY D; HAUSKE JAMES R; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds comprising a sulfonamide moiety, and the screening of those libraries for biological activity, e.g., in animal models of psychosis.