CAS: 14599-46-3; 5-Carboxy-2'-Deoxyuridine

相似化合物

5116-24-5 4494-26-2 3424-98-4

上下游产品

5-ethoxycarbonyl-2'-deoxyuridine thymidine 2'-deoxy-5-trifluoromethyluridine 1,3,4-tri-O-acetyl-2-deoxy-β-D-erythro-pentopyranose5'-O-(4,4'-dimethoxytrityl)-5-carboxyethyl-2'-deoxyuridine

📜三氟胸苷置于水体系中,化学反应生成Tas-102杂质
参考文献:三氟胸苷的稳定性:在缓冲水溶液中水解.
标题:三氟胸苷的稳定性:在缓冲水溶液中水解.
摘要:已使用HPLC方法研究了三氟胸苷在水溶液以及硼酸盐和磷酸盐缓冲液中的分解.在水溶液中,加速的研究表明,在4摄氏度下,可以预测到30%的存储寿命(损失10%),但是蒸汽灭菌会导致广泛的故障.在ph范围为4-8的硼酸盐和磷酸盐缓冲液中,动力学和分解途径存在很大差异.在硼酸盐缓冲液中抑制产生氢氧根离子攻击的5-羧基-2'-脱氧尿苷.发现在磷酸盐缓冲液中分解的复杂动力学,并提出了可能的解释.在缓冲溶液中进行蒸汽灭菌还会导致不可接受的故障.
Doi:10.1111/j.2042-7158.1981.Tb13780.X

专利信息

专利号:EP-1600451-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-l-nucleosides

专利号:EP-1600452-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleosides

专利号:EP-1634888-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleosides

专利号:US-4396605-A
优先权日:1981-09-18
标 题 :Bis-thymosine α-1 compounds
发明人：BIRR CHRISTIAN
权利人:MAX PLANCK GESELLSCHAFT
摘要:Bis-thymosine α-1 consisting of two desacetylthymosine α-1 un N-terminally linked by a bridge bond of 1 to 10 carbon atoms, especially an α,ω-diacyl residue with 2 to 10 carbon atoms. This new compound is made by converting a synthetic desacetylthymosine α-1 in which all functional groups of amino acids 1 through 28, except the N-terminal group, are blocked by protective groups conventional in peptide synthesis with a coupling compound of 1 to 10 carbon atoms and that reacts with NH 2 groups, in a polar solvent, and then removing the protective groups.