专利号:US-8288545-B2 优先权日:2006-07-21 标 题:Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use 发明人:YANACHKOV IVAN; WRIGHT GEORGE E 权利人:YANACHKOV IVAN; WRIGHT GEORGE E; GLSYNTHESIS INC 摘要:This invention features bis-amides of pyrophosphoric acid and bisphosphonic acids, their preparation, and their use in synthesis of P 1 ,P 4 -dinucleoside tetraphosphates, tetraphosphonates, and related compounds.
专利号:US-9688709-B2 优先权日:2010-06-04 标题:Phosphaplatins and their use for treatment of cancers 发明人:BOSE RATHINDRA N 权利人:BOSE RATHINDRA N; UNIV OHIO 摘要:Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically enriched or enantiopure trans-cyclohexanediamine ligands, and synthesis of these complexes, are provided. Efficacies and toxicities of the phosphaplatin compounds are determined toward a variety of cancers, including sensitive and resistant ovarian cancers, head and neck, and colon cancers. Compositions comprising the platinum complexes, and methods for treatment of proliferative diseases or disorders by means of the complexes or the compositions comprising them are disclosed.
专利号:US-2015361124-A1 优先权日:2013-01-22 标 题:Method for the solid-phase based synthesis of phosphate-bridged nucleoside conjugates 发明人:SARAC IVO; MEIER CHRIS 权利人:UNIVERSITÄT HAMBURG; UNIV HAMBURG 摘要:A method for producing phosphate-bridged nucleoside conjugates, in particular poly- or oligonucleosides. In the method, an immobilized cyclosaligenyl derivative of a nucleoside, nucleotide, poly- or oligonucleotide, poly- or oligonucleoside, or an analog thereof, is synthesized, and the subsequent reaction with a nucleophile yields the desired phosphate-bridged nucleoside conjugate, which may subsequently be released from the solid phase.
专利号:US-7686239-B2 优先权日:2001-12-21 标 题 :Synthesis of calcium phosphates by mechano-chemical process 发明人:TOFIGHI ALIASSGHAR N; REY CHRISTIAN 权利人:Etex Corportation 摘要:A low crystallinity calcium phosphate powder is prepared by mechanically grinding a calcium phosphate solid under grinding forces local heating sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate solid to less than about 100 nm. The method is useful for making any calcium phosphate material by solid-solid mixing and high energy grinding.
专利号:US-2003120351-A1 优先权日:2001-12-21 标 题:Synthesis of calcium phosphates by mechano-chemical process
专利号:US-5820841-A 优先权日:1996-09-19 标 题 :Hydrogen peroxide complexes of inorganic salts and synthesis thereof 发明人:CHEN XIAOLAN; JACOBS PAUL TAYLOR; LIN SZU-MIN 权利人:ETHICON INC 摘要:A method of making an inorganic salt-hydrogen peroxide complex includes the following steps: (a) mixing the inorganic salt with sufficient water for a time sufficient to form a soft paste, (b) mixing the paste with an aqueous hydrogen peroxide solution to form a hydrogen peroxide-containing paste, and (c) drying the hydrogen peroxide-containing paste. A hydrate method of making Na4P2O7.3H2O2 includes the steps of: mixing sodium pyrophosphate decahydrate solid with an aqueous solution of hydrogen peroxide having a concentration of less than 30%, and drying the mixture. Compositions of matter include K2HPO4.3H2O2, KH2PO4.H2O2 Ca2P2O7.nH2O2, Ca2P2O4.nH2O2, Na2SO4.nH2O2, K2SO4.nH2O2, Na2SiO3.nH2O2 and Na2SiO7.nH2O2.
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