CAS: 108945-35-3; 3-((Z)-((3Ar,4R,5R,6As)-4-((S,E)-3-Cyclohexyl-3-Hydroxyprop-1-En-1-yl)-5-Hydroxyhexahydro-2H-Cyclopenta[b]Furan-2-Ylidene)Methyl)Benzoic Acid

该化合物是一种合成合成化合物,属于丙烯类类同,主要被承认为具有以下作用:作为PESE2型亚型的Pestallandin E受体性有选择性的刺激剂.塔普罗斯特内具有抗炎和血管血管炎的特征,因此对各种治疗应用感兴趣,特别是血管健康和炎症的治疗.该化合物的特点是能够调节生物过程,如肌肉平稳放松和抑制聚聚聚板.其药理学特征表明,管理心血管疾病和其他炎性紊乱的潜在好处.与许多合成化合物一样,塔普罗斯特内的安全性,功效和具体行动机制是正在进行的研究的主题,在临床环境中的使用以监管批准和临床试验结果为指导.

结构式图片

合成工艺路线路线简述

    📜<<(5Z,13E,9α,11α,15S)-2,3,4-Trinor-1,5-Inter-M-Phenylene-6,9-Epoxy-11,15-Dihydroxy-15-Cyclohexyl-16,17,18,19,20-Pentanor>Prosta-5,13-Dienoic Acid> Methyl Ester,3-[(3Ar,4R,5R,6As)-4-((E)-(S)-3-Cyclohexyl-3-Hydroxy-Propenyl)-5-Hydroxy-Hexahydro-Cyclopenta[b]Furan-(2E)-Ylidenemethyl]-Benzoic Acid Methyl Ester 反应生成他前列烯
    参考文献:Seipp,U.
    标题:Seipp,U.

    专利信息


    专利号:US-6653345-B2
    优先权日:1997-09-16
    标题 :C-C chemokine synthesis inhibitor
    发明人:KURUMATANI HAJIMU; SASAKI RIE; KUMAGAI HIROKI
    权利人:TORAY INDUSTRIES
    摘要:A method of inhibiting mammalian C-C chemokine production by using a mammalian C-C chemokine synthesis inhibitor containing a prostaglandin I derivative as an active component to treat a variety of circulatory diseases, inflammation, allergic diseases, and renal diseases.

    专利号:US-8076315-B2
    优先权日:2005-10-14
    标题:Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists
    发明人:CARLEY DAVID W; RADULOVACKI MIODRAG
    权利人:CARLEY DAVID W; RADULOVACKI MIODRAG; UNIV ILLINOIS
    摘要:This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or a combination of prostanoid receptor antagonists (eg. ramatroban, ifetroban, diphloretin, phosphate, polyphloretin phosphate, seratrodast, SC19220). The prostanoid receptor antagonist or combination of prostanoid receptor antagonists can be administered in conjunction with one or more serotonin receptor agonists, one or more cannabinoids receptor agonists, one or more serotonin reuptake inhibitors, one or more noradrenalin reuptake inhibitors, a combination of reuptake inhibitors, an inhibitor of prostanoid synthesis, or any combination of the foregoing.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Joshi R, Paracha TU, Mostafa MM, Thorne AJ, Jayasinghe V, Yan D, Hamed O, Newton R, Giembycz MA. Comparison of the Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression. J Pharmacol Exp Ther. 2024 Sep 18;391(1):64-81. doi: 10.1124/jpet.124.002226. 82(5):2407-2413. doi: 10.1021/acs.joc.6b02829. Epub 2017 Feb 10. 30(1):161-6. doi: 10.1016/j.jdiacomp.2015.09.006. Epub 2015 Sep 12.
    101:127-34. doi: 10.1016/j.mvr.2015.07.004. Epub 2015 Jul 17. (4):CD000986. doi: 10.1002/14651858.CD000986.pub3. 30(2):150-5. 79(3):586-95. doi: 10.1124/mol.110.069674. Epub 2010 Dec 20. 120(9):1863-71. doi: 10.1002/lary.21011. 183(10):6788-99. doi: 10.4049/jimmunol.0902738. Epub 2009 Oct 30. 324(2):815-26. doi: 10.1124/jpet.107.129312. Epub 2007 Oct 25. 72(4):289-99. doi: 10.1016/j.plefa.2004.12.002. 43(6):795-807. doi: 10.1097/00005344-200406000-00009. 70(5):423-9. doi: 10.1016/j.plefa.2003.08.022. 1(1):29-40. 134(2):313-24. doi: 10.1038/sj.bjp.0704252.
    16: Rudd JA, Qian Ym, Tsui KK, Jones RL. Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat: comparison of vagus nerve and NANC innervation of the colon. Br J Pharmacol. 2000 Feb;129(4):782-90. doi: 10.1038/sj.bjp.0703090.

    合成参考文献


    参考文献:10.1007/bf00420913
    摘要:Portolés MT, Catalá M, Antón A, Pagani R. Hepatic response to the oxidative stress induced by E. coli endotoxin: Glutathione as an index of the acute phase during the endotoxic shock. Molecular and Cellular Biochemistry. 1996 Sep;159(2):115–21. doi: 10.1007/bf00420913.
    参考文献:10.1007/bf00184102
    摘要:Jakschik J, Decker P, Hirner A. [Significance of therapy timing for the effects of systemic and local therapy with the ACE inhibitor captopril on intestinal microcirculation in manifest mesenteric ischemia. An animal experiment study in the swine]. Langenbecks Arch Chir. 1995;380(5):273–80. doi: 10.1007/bf00184102.
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