CAS: 1074-59-5; 3-(1H-Imidazol-4-yl)Propanoic Acid

该化合物是一种有机化合物,其特征是其imidazole环结构,即五人组成的含有两个氮原子的环环化合物.该物质具有一种丙诺酸侧链,有助于其酸性.该物质通常是白色至白晶状固体,溶于水和极有机溶剂中,反映其极分功能组.它的存在允许潜在的生物活动,因为伊迪佐尔环经常参与各种生物化学过程,包括酶催化和代谢途径的中间体.此外,该化合物可能表现出由碳箱酸组组成的缓冲能力,使其在生物化学应用中有用.其特性使它与药物研究有关,特别是在针对各种生物系统的药物开发中.

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MSDS等安全信息

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上下游产品

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合成工艺路线路线简述

  • 合成目标产物 3-(Imidazol-4-yl)Propionic Acid 主要起始原料 (2E)-3-(1H-Imidazole-4-yl)Propenoic Acid
  • (文献来源)合成步骤主要原料 (2E)-3-(1H-Imidazole-4-yl)Propenoic Acid
📜D,L-Histidine 反应生成3-(咪唑-4-基)丙酸
参考文献:Ackermann,Hoppe-Seyler'S Zeitschrift Fur Physiologische Chemie,1910,Vol. 65,P. 508
标题:Ackermann,Hoppe-Seyler'S Zeitschrift Fur Physiologische Chemie,1910,Vol. 65,P. 508

海关参考信息

专利信息


专利号:US-9040480-B2
优先权日:2006-02-08
标题:Synthesis of glucagon-like peptide
发明人：WERBITZKY OLEG; VARRAY STÉPHANE; GIRAUD MATTHIEU; MEININGHAUS CARSTEN
权利人:LONZA AG
摘要:A new method of synthesizing GLP-1 peptide is devised.

专利号:WO-2020020904-A1
优先权日:2018-07-23
标题:Therapeutic uses of glp-2 agonists
发明人：LINDSTRÖM ERIK; SKARBALIENE JOLANTA
权利人:ZEALAND PHARMA AS
摘要:The invention relates to the use of GLP-2 agonists to modulate bile acid metabolism. In particular, it is believed that GLP-2 agonists may be capable of inhibiting bile acid synthesis, and so are useful for the treatment of conditions in which inhibition of bile acid synthesis is beneficial. Such conditions include primary bile acid diarrhea, secondary bile acid diarrhea and conditions which cause or contribute to cholestasis. The invention further relates to the use of FGF19 and C4 as biomarkers to monitor bile acid synthesis and homoeostasis, e.g. in SBS patients.

专利号:AU-2007214088-B2
优先权日:2006-02-08
标题:Synthesis of glucagon-like peptide

专利号:ES-2364982-T3
优先权日:2006-02-08
标 题 :SYNTHESIS OF SIMULAR PEPTIDES TO GLUCAGON.

专利号:CA-2641053-A1
优先权日:2006-02-08
标题:Synthesis of glucagon-like peptide

专利号:RU-2141321-C1
优先权日:1994-03-04
标题:Use of imidazole derivatives for preparing pharmaceutical composition showing activity to angiotensin receptors at1 and at2, some of these compounds, method of synthesis of imidazole derivatives and pharmaceutical composition based on thereof

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合成参考文献


参考文献:10.1016/j.cmet.2020.07.012
摘要:Koh A, Mannerås-Holm L, Yunn NO, Nilsson PM, Ryu SH, Molinaro A, Perkins R, Smith JG, Bäckhed F. Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation. Cell Metab. 2020 Oct 06;32(4):643–653.e4.
参考文献:10.1093/jn/91.2.189
摘要:Block WD, Westhoff MH, Steele BF. Histidine Metabolism in the Human Adult: Histidine blood tolerance, and the effect of continued free L-histidine ingestion on the concentration of imidazole compounds in blood and urine. The Journal of Nutrition. 1967 Feb;91(2):189–94. doi: 10.1093/jn/91.2.189.
参考文献:10.1515/bchm2.1960.319.1.17
摘要:LIST PH, REITH H. [The basic ingredients of fungi. 10. Imidazole derivatives in the agaric Coprinus atramentarius Bull]. Hoppe Seylers Z Physiol Chem. 1960;319():17–21. doi: 10.1515/bchm2.1960.319.1.17.
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