CAS: 104700-96-1; (3S,5R,10S,13R,14R,17R)-17-((R,E)-7-Hydroxy-6-Methylhept-5-En-2-yl)-4,4,10,13,14-Pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-3-Ol

该化合物是一种生物活性三叶类化合物,来自药用蘑菇Ganoderma Coleminum(Reishi),具有显著的药理特性,包括潜在的抗炎,抗氧化剂和肝脏保护效应.结构上,它属于以四环核为特征的,含氢氧和碳基功能组的拉诺斯坦型三叶类人.研究显示,甘诺洛尔B可以通过抑制胆固醇合成来调节脂肪新陈代谢,从而引起对代谢紊乱研究的兴趣.其低毒性和自然来源进一步增强了其对生物医学应用的吸引力.HPLC和LC-MS等分析方法通常用于隔离和定性.目前正在进一步调查,以阐明其机制和治疗潜力.

结构式图片

合成工艺路线路线简述

    📜羊毛甾醇置于盐酸,Potassium Osmate(Vi) Dihydrate,Potassium Permanganate,18-冠醚-6,四丁基碘化铵,二异丁基氢化铝,对甲苯磺酸,一水合肼,N-甲基吗啉氧化物,N,N-二异丙基乙胺体系中,用 四氢呋喃,正己烷,二氯甲烷,水,丙酮,甲苯,叔丁醇,二乙二醇 用作溶剂,化学反应 58.67H,反应生成灵芝醇b
    参考文献:10.1039/d4Ob00641K
    标题:10.1039/d4Ob00641K
    摘要:
    Doi:10.1039/d4Ob00641K

    海关参考信息

    专利信息


    专利号:US-6726911-B1
    优先权日:1999-03-09
    标 题 :Biologically active compounds of Ganoderma pfeifferi DSM 13239
    发明人:JUELICH WOLF; LINDEQUIST ULRIKE; JANSEN ROLF; MOTHANA RAMZI
    权利人:GANOMYCIN
    摘要:The present invention relates to novel biologically active compounds from fungi of the species Ganoderma pfeifferi DSM 13239, processes for their preparation, and their use. From the fruit body and mycelium of the species Ganoderma pfeifferi DSM 13239, extracts can be obtained which have antimicrobial activity and are suitable as preserving agents, for pharmaceutical and cosmetic preparations, for controlling infections, and for use in fish breeding. Antimicrobially active substances called ganomycins having activity against multiresistant germs are isolated from the extracts. The total synthesis of the ganomycins and their derivatization enables their use an antibiotics.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Arisawa M, Fujita A, Saga M, Fukumura H, Hayashi T, Shimizu M, Morita N. Three new lanostanoids from Ganoderma lucidum. J Nat Prod. 1986 Jul-Aug;49(4):621-5. doi: 10.1016/j.fct.2012.12.016. Epub 2012 Dec 21. doi: 10.18632/oncotarget.14634.

    合成参考文献


    参考文献:10.1126/science.1174621
    摘要:Lingwood D, Simons K. Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 01;327(5961):46–50. doi: 10.1126/science.1174621.
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