专利号:US-6726911-B1 优先权日:1999-03-09 标 题 :Biologically active compounds of Ganoderma pfeifferi DSM 13239 发明人:JUELICH WOLF; LINDEQUIST ULRIKE; JANSEN ROLF; MOTHANA RAMZI 权利人:GANOMYCIN 摘要:The present invention relates to novel biologically active compounds from fungi of the species Ganoderma pfeifferi DSM 13239, processes for their preparation, and their use. From the fruit body and mycelium of the species Ganoderma pfeifferi DSM 13239, extracts can be obtained which have antimicrobial activity and are suitable as preserving agents, for pharmaceutical and cosmetic preparations, for controlling infections, and for use in fish breeding. Antimicrobially active substances called ganomycins having activity against multiresistant germs are isolated from the extracts. The total synthesis of the ganomycins and their derivatization enables their use an antibiotics.
1: Arisawa M, Fujita A, Saga M, Fukumura H, Hayashi T, Shimizu M, Morita N. Three new lanostanoids from Ganoderma lucidum. J Nat Prod. 1986 Jul-Aug;49(4):621-5. doi: 10.1016/j.fct.2012.12.016. Epub 2012 Dec 21. doi: 10.18632/oncotarget.14634.
合成参考文献
参考文献:10.1126/science.1174621 摘要:Lingwood D, Simons K. Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 01;327(5961):46–50. doi: 10.1126/science.1174621.