CAS: 10147-11-2; Prop-2-Yn-1-Ylbenzene

该化合物是一种有机化合物,其特征是碳原子之间的三重结合,碳原子之间的三重结合为3-碳丙烷链的第三碳,该结构具有一个苯基组(苯环),附于三碳丙烯链的第三碳,具有独特的特性,包括它有可能参与各种典型的藻类化学反应,例如附加反应.该化合物一般没有颜色,不光彩,不光彩黄色液体,有独特的芳香味.该化合物在水中相对不溶,但在有机溶剂中可溶解,许多碳氢化合物都常见.3-苯-1-prayne用于有机合成,并可作为生产更复杂的分子的中间体.安全考虑包括在通风良好的地区处理该物质,并使用适当的个人防护设备,因为接触时可能会对健康造成危害.该化合物的再活性和结构特征使它在学术研究和工业应用中成为有价值的化合物.

结构式图片

相似化合物

40307-11-7 16520-62-0 30342-96-2

欧盟法规

C&L通报

上下游产品

CAS号673-32-5 1-苯基-1-丙炔 | CAS号100-39-0 溴化苄 | CAS号74-86-2 乙炔 | CAS号859944-01-7 (3-bromo-allyl)... | CAS号4187-87-5 1-苯基-2-丙炔-1-醇 | CAS号106-96-7 溴代丙炔 | CAS号100-58-3 苯基溴化镁 | CAS号627-09-8 乙酸炔丙酯 | CAS号122-78-1 2-苯基乙醛 | CAS号110615-11-7 3-phenyl-N-prop... | CAS号3623-15-2 1-苯基-2-丙炔-1-酮 | CAS号141694-60-2 3,3-diiodopropy... | CAS号18753-56-5 5-Benzyl-3-phen... | CAS号104-53-0 3-苯丙醛 | CAS号122-97-4 3-苯丙醇 | CAS号103-79-7 苯基丙酮 | CAS号292638-84-7 phenylene-ethylene | CAS号300-57-2 烯丙基苯 | CAS号873-66-5 反-β-甲基苯乙烯

合成工艺路线路线简述

  • 合成目标产物 3-Phenyl-1-Propyne 主要起始原料 Trimethyl(3-Phenylprop-1-Ynyl)Silane
  • (文献来源)合成步骤主要原料 Trimethyl(3-Phenylprop-1-Ynyl)Silane
📜苯基丙酮置于吡啶,Sodium Carbonate体系中,化学反应生成3-苯-1-丙炔
参考文献:Jaeckel,K.-P.; Hanack,M.,Chemische Berichte,1977,Vol. 110,P. 199-207
标题:Jaeckel,K.-P.; Hanack,M.,Chemische Berichte,1977,Vol. 110,P. 199-207

专利信息


专利号:US-2010143980-A1
优先权日:2007-02-22
标题:Synthesis of novel xylosides and potential uses thereof
发明人:BALAGURUNATHAN KUBERAN; MANIVANNAN ETHIRAJAN; XYLOPHONE V VICTOR; TRAN VY MY; NGUYEN KHIEM
权利人:BALAGURUNATHAN KUBERAN; MANIVANNAN ETHIRAJAN; XYLOPHONE V VICTOR; TRAN VY MY; NGUYEN KHIEM
摘要:The present invention includes a xyloside for use in inducing synthesis of a glycosaminoglycan in a cell, the xyloside having a chemical structure of one of Formula (1), Formula (2), Formula (3), Formula (4), Formula (5), Formula (6), Formula (7), Formula (8), Formula (9), or Formula (10) as shown herein. Also, the present invention includes a method of making a xyloside for use in inducing synthesis of a glycosaminoglycan in a cell, wherein the method is performed with “Clickâ€? chemistry. Additionally, the present invention includes a method of administering a xyloside so as to induce synthesis of a glycosaminoglycan in a cell.

专利号:US-2006183758-A1
优先权日:2005-02-17
标 题:Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
发明人:BEARD CHARLES D; LEE VING J; WHITTLE C E
权利人:CB RES AND DEV INC
摘要:Methods of synthesis of intermediates that are useful as bioisosteres of the indole, benzofuran and benzothiophene scaffold are disclosed.

专利号:US-2002037834-A1
优先权日:2000-09-08
标题 :Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
发明人:ASTATKE MEKBIB; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention relates to cationic and polycationic compositions and methods for enhancing synthesis of nucleic acid molecules. In a preferred aspect, the invention relates to inhibition or control of nucleic acid synthesis, sequencing or amplification. Specifically, the present invention discloses cationic and polycationic molecules, compounds, and compositions having affinity for double-stranded and/or single-stranded nucleic acid molecules and/or single-stranded/double-stranded nucleic acid complexes (e.g., primer/template complexes, double-stranded templates, single-stranded templates or single-stranded primers) for use in such enhanced synthesis. The cationic and polycationic molecules, compounds, and compositions of the invention are capable of inhibiting nonspecific nucleic acid synthesis at ambient temperature. Thus, in a preferred aspect, the invention relates to “hot startâ€? synthesis of nucleic acid molecules. Accordingly, the invention prevents non-specific nucleic acid synthesis at low temperatures, for example during reaction set up. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the cationic and polycationic molecules, compounds, and compositions of the invention. The invention also relates to compositions prepared for carrying out the methods of the invention and to compositions made after or during such methods. The invention also generally relates to compositions useful for inhibiting or preventing degradation of various nucleic acid molcules.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-2024286903-A1
优先权日:2023-02-24
标 题 :Crystalline Sp-Sp2 Hybridized Carbon Allotropes through Dynamic Covalent Synthesis
发明人:ZHANG WEI; HU YIMING
权利人:UNIV COLORADO REGENTS
摘要:Disclosed is a method for the synthesis of crystalline -graphyne which exhibits an ABC stacking pattern in the crystal structure. Alkyne metathesis is used to reversibly cleave and reform bonds between sp-hybridized carbon atoms to create an sp and sp 2 -hybridized carbon network. An exemplary method includes providing a first hexa-alkynyl substituted benzene co-monomer (e.g., HPB) and a second hexa-alkynyl substituted co-monomer (e.g., HHEB), and undergoing an alkyne metathesis reaction in the presence of a catalyst. During the reaction, small short chain alkyne byproducts can be removed, to drive the reaction toward the formation of the -graphyne polymer product, while the larger alkyne byproducts can facilitate the self-correction process that will minimize the structural defects in the resulting -graphyne.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人:NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

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主要参考文献

参考标题:Ancillary Ligand-Free Copper Catalysed Hydrohydrazination Of Terminal Alkynes With Nh2Nh2
作者:Jesse L. Peltier,Rodolphe Jazzar,Mohand Melaimi,Guy Bertrand
摘要:An Efficient And Selective Cu-Catalysed Hydrohydrazination Of Terminal Alkynes With Parent Hydrazine Is Reported. The Methodology Tolerates A Broad Range Of Functional Groups, Allows For The Synthesis Of Symmetrical And...

合成参考文献


摘要:Ogasawara, M., Science of Synthesis, (2008) 44, 62.
摘要:Stolley, R. M.; Louie, J., Science of Synthesis Knowledge Updates, (2013) 2, 39.
摘要:Campbell, M. J.; Toste, F. D., Science of Synthesis Knowledge Updates, (2012) 1, 165.
摘要:Anderson, E. A.; Lim, D. S. W., Science of Synthesis Knowledge Updates, (2015) 1, 89.
摘要:Durand, A.; Hemeon, I.; Singer, R. D., Science of Synthesis Knowledge Updates, (2013) 2, 144.
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