CAS: 93-30-1; 2-Methoxyphenamine Hcl

该化合物是属于苯乙胺类别的化学化合物,其特点是存在一个甲氧基组(-OCH3)和一个附属于苯环的甲胺组(-NH2),该化合物一般是白色的脱白晶状固体,在有机溶剂中可溶解.其分子结构允许它与各种生物系统互动,从而导致其在药理学方面进行调查.甲基苯丙胺具有刺激性,并研究其对...

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上下游产品

nitromethane 1-(2-methoxyphenyl)propan-2-one methylamine methyl iodide O-desmethylmethoxyphenamine (+)-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-methyl-amine (-)-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-methyl-amine benzyl-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-methyl-amine

合成工艺路线路线简述

    📜邻甲氧基苯丙酮置于lithium Aluminium Tetrahydride体系中,用 甲醇 作为反应溶剂,化学反应 22.0H,反应生成 甲氧那明
    参考文献:盐酸甲氧那明的合成方法
    标题:盐酸甲氧那明的合成方法
    摘要:本发明涉及医药原料和化工中间体合成的技术领域,尤其是一种盐酸甲氧那明的合成方法,将邻甲氧基苯基丙酮和甲胺甲醇溶液加入反应釜中进行反应,反应得到席夫碱;再在反应得到的席夫碱中加入金属还原剂进行席夫碱的还原.该盐酸甲氧那明的合成方法的成本低,产品含量高,容易工业化,摩尔收率大于82%.

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    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:KR-101513003-B1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2008107598-A1
    优先权日:2006-10-05
    标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: He Y, Lou X, Jin Z, Yu L, Deng L, Wan H. Mahuang decoction mitigates airway inflammation and regulates IL-21/STAT3 signaling pathway in rat asthma model. J Ethnopharmacol. 2018 Oct 5;224:373-380. doi: 10.1016/j.jep.2018.06.011. Epub 2018 Jun 12. doi: 10.1016/j.chroma.2018.01.027. Epub 2018 Jan 12. doi: 10.1177/1753465817711187.
    4: Kim J, Choi K, Chung DS. In-line coupling of single-drop microextraction with capillary electrophoresis-mass spectrometry. Anal Bioanal Chem. 2015 Nov;407(29):8745-52. doi: 10.1007/s00216-015-9028-0. Epub 2015 Sep 24. doi: 10.1016/j.chroma.2015.05.012. Epub 2015 May 14. doi: 10.1021/acs.analchem.5b00971. Epub 2015 May 6. doi: 10.1002/elps.201400135. Epub 2014 Aug 19. doi: 10.1016/j.chroma.2014.03.017. Epub 2014 Mar 12. doi: 10.1007/s00216-014-7723-x. Epub 2014 Mar 15. doi: 10.1002/jmr.2271. doi: 10.1016/j.aca.2012.11.049. Epub 2012 Dec 5. doi: 10.1111/j.1440-1843.2010.01785.x. Epub 2010 Jun 9. doi: 10.1016/j.ecl.2009.10.011. doi: 10.1016/j.chroma.2008.08.091. Epub 2008 Sep 2. doi: 10.1255/ejms.926. doi: 10.1080/08927010802340309. Epub 2006 Jul 25. Epub 2006 Jun 22. Epub 2003 Nov 18.

    合成参考文献


    参考文献:10.1007/s00216-010-3484-3
    摘要:Peters RJB, Oosterink JE, Stolker AAM, Georgakopoulos C, Nielen MWF. Generic sample preparation combined with high-resolution liquid chromatography–time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and Bioanalytical Chemistry. 2010 Feb 16;396(7):2583–98. doi: 10.1007/s00216-010-3484-3.
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