CAS: 875337-44-3; N-((3-Fluoro-4-((2-(1-Methyl-1H-Imidazol-4-yl)Thieno[3,2-B]Pyridin-7-yl)Oxy)Phenyl)Carbamothioyl)-2-Phenylacetamide
该化合物是一个复杂的有机化合物,其独特的结构特征包括:三丁诺[3,2-b]pyridine momeity,一个碳氨基乙酰集团和一个苯丙胺脊柱.该化合物展示了潜在的生物活动,经常因其在药用化学中的作用而进行调查,特别是在针对特定生物途径的药品开发过程中.氟丙烯的存在可能会增强脂性和代谢稳定性,而氟化物成分则有助于其与生物目标的潜在互动.该化合物的溶性,稳定性和再活性可因环境条件和其他化学物种的存在而变化.与许多复杂的有机分子一样,其合成和定性的先进技术在针对特定生物路径发展过程中的作用,特别是在研制药物结构中,例如NMR,质量和化学的化合物.
- 英文名称N-((3-Fluoro-4-((2-(1-Methyl-1H-Imidazol-4-yl)Thieno[3,2-B]Pyridin-7-yl)Oxy)Phenyl)Carbamothioyl)-2-Phenylacetamide
- 中文名称N-(3-氟-4-(2-(1-甲基-1H-咪唑-4-基)噻吩并[3,2-B]吡啶-7-氧基)苯基氨基硫代甲酰基)-2-苯乙酰胺
- IUPAC名称N-((3-fluoro-4-((2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)carbamothioyl)-2-phenylacetamide
- 其它别名N-(3-Fluoro-4-(2-(1-Methyl-1H-Imidazol-4-yl)Thieno[3,2-B]Pyridin-7-Yloxy)Phenylcarbamothioyl)-2-Phenylacetamide; N-(3-Fluoro-4-(2-(1-Methyl-1H-Imidazol-4-yl)Thieno[3,2-B]Pyridin-7-Yloxy)Phenylcarbamothioyl)-2-Phen; N-[[[3-Fluoro-4-[[2-(1-Methyl-1H-Imidazol-4-yl)Thieno[3,2-B]Pyridin-7-Yl]Oxy]Phenyl]Amino]Thioxomethyl]-Benzeneacetamide; N-(3-Fluoro-4-(2-(1-Methyl-1H-Imidazol-4-yl)Thieno[3,2-B]Pyridin-7-Yloxy)Phenylcarbamothioyl)-
- CAS编号875337-44-3
- MFCD编号:MFCD17779287
- EINECS号:812-647-3
- FDA UNII编号:93M6577H9D
- 分子式:C26H20FN5O2S2分子量:517.61
- 产品CID: 1883166
- 产品分类生物化工 → 抑制剂 → 蛋白酪氨酸激酶
物理性质
- 沸点195.7 °C at 760 mmHg
- 闪点72.1 °C
- 密度1.41
- pKa:10.07±0.70(预测)
- PSA:151.93
- LogP:6.7447
- 折射率1.707
- 溶解性≥25.9 mg/mL In DMSO; Insoluble In Etoh; Insoluble In H2O
- 外观形态白色至类白色固体
- 储存条件储存在 -20°C
- 产品应用该化合物是C-MET和VEGFFI1/2/3(分别为IC50=1 NM,3 NM/3 NM/4 NM)的强大,多目标,ATP竞争抑制器,还抑制RON和TIE2;它处于临床调查第1/2阶段;它抑制了C-ME驱动的肿瘤细胞(例如MKN45,NNNG-HOS,SNU-5;IC50 =6-30 NM),非C-MT驱动肿瘤细胞 (例如,HCT116,MDA-MB-231;IC 50 =1-3 ΜM)的扩散;MGC D-265抑制了血清-星系MKKNK45细胞(包括ERK,AKT,STAT3和FAK)的传播,并诱导出MK-N45细胞的流行性硬性反应(6 NMM-1 Μ M).
MSDS等安全信息
欧盟法规
C&L通报上下游产品
3-Fluoro-4-(2-(1-Methyl-1H-Imidazol-4-yl)Thienthio[3,2-B]Pyridine-7-Oxy)Aniline 875340-09-3合成工艺路线路线简述
- 69627-03-8 + 25676-75-9 = 875337-44-3
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C1.2 Reagents: Tributyltin Chloride1.3 Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Toluene; Reflux2.1 Reagents: Potassium Carbonate Solvents: Diphenyl Ether; 180 °C2.2 Reagents: Sodium Borohydride Catalysts: Nickel Dichloride Solvents: Methanol,Water; 0 °C2.3 Solvents: Tetrahydrofuran; Rt
标题:Discovery Of A Novel And Potent Series Of Thieno[3,2-B]Pyridine-Based Inhibitors Of C-Met And Vegfr2 Tyrosine Kinases
作者:Claridge,Stephen; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(9) 页码:2793-2798]
403-19-0 + 29313-32-4 + 875340-07-1 = 875337-44-3
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Diphenyl Ether; 180 °C1.2 Reagents: Sodium Borohydride Catalysts: Nickel Dichloride Solvents: Methanol,Water; 0 °C1.3 Solvents: Tetrahydrofuran; Rt
标题:Discovery Of A Novel And Potent Series Of Thieno[3,2-B]Pyridine-Based Inhibitors Of C-Met And Vegfr2 Tyrosine Kinases
作者:Claridge,Stephen; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(9) 页码:2793-2798]
107818-20-2 = 875337-44-3
反应条件:1.1 Reagents: Phosphorus Oxychloride; Reflux2.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C2.2 Reagents: Tributyltin Chloride2.3 Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Toluene; Reflux3.1 Reagents: Potassium Carbonate Solvents: Diphenyl Ether; 180 °C3.2 Reagents: Sodium Borohydride Catalysts: Nickel Dichloride Solvents: Methanol,Water; 0 °C3.3 Solvents: Tetrahydrofuran; Rt
标题:Discovery Of A Novel And Potent Series Of Thieno[3,2-B]Pyridine-Based Inhibitors Of C-Met And Vegfr2 Tyrosine Kinases
作者:Claridge,Stephen; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(9) 页码:2793-2798
📜3-Fluoro-4-(2-(1-Methyl-1H-Imidazol-4-yl)Thienthio[3,2-B]Pyridine-7-Oxy)Aniline,异硫氰酸苯乙酰酯 以 四氢呋喃 作为反应溶剂,化学反应生成 Mgcd-265 类似物
参考文献:Discovery Of A Novel And Potent Series Of Thieno[3,2-B]Pyridine-Based Inhibitors Of C-Met And Vegfr2 Tyrosine Kinases
标题:Discovery Of A Novel And Potent Series Of Thieno[3,2-B]Pyridine-Based Inhibitors Of C-Met And Vegfr2 Tyrosine Kinases
摘要:A Series Of Thieno[3,2-B]Pyridine-Based Inhibitors Of C-Met And Vegfr2 Tyrosine Kinases Is Described. The Compounds Demonstrated Potency With Ic50 Values In The Low Nanomolar Range In Vitro While The Lead Compound Also Showed In Vivo Activity Against Various Human Tumor Xenograft Models In Mice. Further Exploration Of This Class Of Compounds Is Underway. (C) 2008 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2008.04.009
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2933310010-吡啶 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
J. M. Besterman, M. Fournel, I. Dupont, C. Bonfils, M. Dubay, H. Ste-Croix, C. R. Maroun; MethylGene, Inc., Montreal, QC, Canada, Potent preclinical antitumor activity of MGCD265, an oral Met/VEGFR kinase inhibitor in phase II clinical development, in combination with taxanes or erlotinib, J Clin Oncol 28, 2010 (suppl; abstr e13595).
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