专利号:US-5939304-A 优先权日:1997-06-05 标题:Method for synthesis of anhydrothrombin 发明人:SUZUKI TOYOAKI; HOSOKAWA KAZUYA; NAGATA MASANORI 权利人:FUJIMORI KOGYO CO 摘要:A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields. n The method comprises n (A) a step of causing an active serine residue site of thrombin to react with an inhibitor, n (B) a step of performing an alkali treatment at a pH of not less than 11, and n (C) a step of performing an operation of recovery, and carries out these steps sequentially in the order mentioned, and is characterized by causing at least the step of performing the operation of recovery to proceed in the presence of at least one compound selected from the group consisting of polyhydric alcohols and saccharides, and a salt or an amphoteric electrolyte.
专利号:US-2023174567-A1 优先权日:2020-05-22 标题:Synthesis of fluorinated nucleotides 发明人:ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG 权利人:MERCK SHARP & DOHME LLC 摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)
专利号:WO-2024165611-A1 优先权日:2023-02-07 标题:Production of a disaccharide and/or milk oligosaccharide by a cell with reduced synthesis of udp-glcnac 发明人:BEAUPREZ JOERI; DECOENE THOMAS; VERCAUTEREN ANNELIES 权利人:INBIOSE NV 摘要:The present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. The invention provides a cell for production of a disaccharide and/or an oligosaccharide like a milk oligosaccharide wherein synthesis of UDP-N-acetylglucosamine in said cell is rendered less functional. The invention further provides use of said cell in a cultivation or incubation. The invention also describes methods for the production of a disaccharide and/or an oligosaccharide like a milk oligosaccharide using said cell as well as the purification of said disaccharide and/or oligosaccharide like a milk oligosaccharide.
专利号:WO-2023204823-A1 优先权日:2022-04-23 标题 :Process for synthesis of lignocellulosic based bioproducts 发明人:JAIN ARPAN 权利人:JAIN ARPAN 摘要:The present invention relates to a process for the synthesis of lignocellulosic-based bioproducts. The process involves the biochemical conversion of lignocellulosic biomass generated through agriculture, non-agriculture, and forest that produces streams of high-value goods including cosmetic ingredients, nutraceuticals, carbon fiber, activated carbon, graphene, low-calorie sugar, bioplastic, cellulose pulp, and nano-cellulose based aerogel. The process comprises; a process stage-1 for removing the phenolic compounds (lignin) from lignocellulosic biomass as well as decreasing the crystallinity of the cellulose using alkaline modified ethyl-hydro-oxides (m-EHOs) extraction, a process stage-2 for removal of the hemicellulose fraction of the holocellulose using mild sulfuric acid extraction, and a process stage-3 for chemically treating cellulose pulp with alkaline modified ethyl-hydro-oxides (m-EHOs) solvent for the production of nano-cellulose and micro-cellulose fractions. Along with the production of high-value goods, the process generates energy.
专利号:WO-2024165524-A1 优先权日:2023-02-06 标 题:Production of a saccharide by a cell with reduced synthesis of lactobionic acid 发明人:BEAUPREZ JOERI; DECOENE THOMAS; VERCAUTEREN ANNELIES 权利人:INBIOSE NV 摘要:The present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. The invention provides a cell for production of a saccharide wherein synthesis of lactobionic acid in said cell is rendered less functional or is knocked out. The invention further provides use of said cell in a cultivation or incubation. The invention also describes methods for the production of a saccharide using said cell as well as the purification of said saccharide.
专利号:US-12391691-B2 优先权日:2018-11-16 标题:Synthesis of key intermediate of KRAS G12C inhibitor compound 发明人:PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY 权利人:AMGEN INC 摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as
参考文献:10.1007/s00467-011-1952-4 摘要:Moreira Guimarães Penido MG, de Sousa Tavares M, Campos Linhares M, Silva Barbosa AC, Cunha M. Longitudinal study of bone mineral density in children with idiopathic hypercalciuria. Pediatr Nephrol. 2012 Jan;27(1):123–30. doi: 10.1007/s00467-011-1952-4.