CAS: 684-78-6; 2,2,2-Trifluoro-N-(2,2,2-Trifluoroacetoxy)Acetamide

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📜三氟乙酸酐置于盐酸羟胺体系中,用83%的收率获得产物n,O-双(三氟乙酰基)羟胺
参考文献:Trifluoroacetonitrile Oxide
标题:Trifluoroacetonitrile Oxide
摘要:
DOI:10.1021/jo00179A031

专利信息

专利号:US-4578475-A
优先权日:1983-02-11
标题 :Novel D-homosteroids
发明人：FUERST ANDOR; MUELLER MARCEL; KERB ULRICH; WIECHERT RUDOLF
权利人:HOFFMANN LA ROCHE
摘要:The novel D-homosteroids of the formula ##STR1## wherein R 1 represents a --CN, â•?NOH or â•?CH--NHOH group; R 2 represents oxo or, where R 1 represents a --CN group, R 2 represents oxo or a --OAc group; or R 1 and R 2 together with carbon atoms 2 and 3 of the steroid skeleton represents a [2,3-d]-fused isoxazole ring, a [3,2-c]-fused pyrazole ring, a [3,2-c]-fused N-acylated pyrazole ring or a [2,3-c]-fused furazan ring; Ac represents an acyl group; R 3 and R 4 represent methyl and R 5 and R 6 together represent an additional bond between carbon atoms 5 and 6 of the steroid skeleton; or R 4 and R 5 together represent --O--, R 3 represents hydrogen or methyl, and R 6 represents hydrogen; R 7 represents hydrogen, lower-alkyl or ethynyl; R 8 represents hydroxy or acyloxy; or R 7 and R 8 together represent a spiroether group of the formula ##STR2## or a spirolactone group of the formula ##STR3## the dotted 16,17-bond is an optional additional carbon-carbon bond; and the dotted 2,3-bond is an additional carbon-carbon bond when R 1 and R 2 together with carbon atoms 2 and 3 form the isoxazole or pyrazole ring or when R 2 represents a --OAc group, n inhibit the synthesis of progesterone in organisms and can be used for fertility control. The novel D-homosteroids can be manufactured by molecular modifications of other D-homosteoids.