CAS: 68280-05-7; N-(2,6-Dimethylphenyl)Isonicotinamide

相似化合物

3034-31-9 33974-32-2 436089-25-7

上下游产品

pyridine-4-carboxylic acid 2,6-dimethylaniline 4-(chlor°Carbonyl)pyridine isonicotinamide 4-(2,6-dimethyl-phenylcarbamoyl)-1-methyl-pyridinium; iodide piperidine-4-formyl-(2,6-dimethyl)aniline 1-ethyl-piperidine-4-carboxylic acid-(2,6-dimethyl-anilide)

📜异烟酸置于氯化亚砜,三乙胺体系中,用 四氢呋喃,吡啶 作为反应溶剂,化学反应 1.0H,反应生成 异烟酸-(2,6-二甲基苯胺)
参考文献:Synthesis And Structure-activity Relationships Of Potential Anticonvulsants Based On 2-Piperidinecarboxylic Acid And Related Pharmacophores
标题:Synthesis And Structure-activity Relationships Of Potential Anticonvulsants Based On 2-Piperidinecarboxylic Acid And Related Pharmacophores
摘要:Using N-(2,6-Dimethyl)Phenyl-2-Piperidinecarboxamide (1) And N-(Alpha-Methylbenzyl)-2-Piperidinecarboxamide (2) As Structural Leads,A Variety Of Analogues Were Synthesised And Evaluated For Anticonvulsant Activity In The Mes Test In Mice. In The N-Benzyl Series,Introduction Of 3-Cl,4-Cl,3,4-Cl-2,Or 3-Cf3 Groups On The Aromatic Ring Led To An Increase In Mes Activity. Replacement Of The Alpha-Methyl Group By Either I-Pr Or Benzyl Groups Enhanced Mes Activity With No Increase In Neurotoxicity. Substitution On The Piperidine Ring Nitrogen Led To A Decrease In Mes Activity And Neurotoxicity,While Reduction Of The Amide Carbonyl Led To A Complete Loss Of Activity. Movement Of The Carboxamide Group To Either The 3-Or 4-Positions Of The Piperidine Ring Decreased Mes Activity And Neurotoxicity. Incorporation Of The Piperidine Ring Into A Tetrahydroisoquinoline Or Diazahydrinone Nucleus Led To Increased Neurotoxicity. In The N-(2,6-Dimethyl)Phenyl Series,Opening Of The Piperidine Ring Between The 1-And 6-Positions Gave The Active Norleucine Derivative 75 (Ed50 = 5.8 Mg Kg(-1),Td50 = 36.4 Mg Kg(-1),Pi = 6.3). Replacement Of The Piperidine Ring Of I By Cycloalkane (Cyclohexane,Cyclopentane,And Cyclobutane) Resulted In Compounds With Decreased Mes Activity And Neurotoxicity,Whereas Replacement Of The Piperidine Ring By A 4-Pyridyl Group Led To A Retention Of Mes Activity With A Comparable Pi. Simplification Of The 2-Piperidinecarboxamide Nucleus Of 1 Into A Glycinecarboxamide Nucleus Led To About A Six-Fold Decrease In Mes Activity. The 2,6-Dimethylanilides Were The Most Potent Compounds In The Mes Test In Each Group Of Compounds Evaluated,And Compounds 50 And 75 Should Be Useful Leads In The Development Of Agents For The Treatment Of Tonic-Clonic And Partial Seizures In Man. (C) 2001 Editions Scientifiques Et Medicales Elsevier Sas.
DOI:10.1016/s0223-5234(00)01206-X