CAS: 676-96-0; Trimethylphosphineoxide

上下游产品

tetramethylphosphonium hydroxide trimethylphosphane dimethyl methane phosphonate methyl iodideformic acid dimethylphosphinic acid methylphosphonic acid

📜甲基氯化镁置于copper Dichloride,三氯氧磷体系中,用 四氢呋喃,甲苯 作为反应溶剂,化学反应 2.0H,以95%的收率获得产物三甲基氧膦
参考文献:一种三甲基氧膦的合成方法
标题:一种三甲基氧膦的合成方法
摘要:本发明公开了一种三甲基氧膦的合成方法,属于化合物制备领域.本发明首先由氯甲烷与镁屑在氮气保护下,在甲苯和四氢呋喃混合溶剂中以溴乙烷为引发剂反应得到甲基氯化镁;该步骤所得产物无需纯化,降温后,直接向上述步骤所得物中加入三氯氧膦,低温下搅拌反应,反应完毕,萃取,油层减压精馏,降温结晶得三甲基氧膦产品,纯度为99.5%以上,收率达95%;且本发明所用溶剂易于回收利用.

专利信息

专利号:US-10793495-B2
优先权日:2015-08-14
标 题:Synthesis of polyaryl substituted aryl compounds
发明人：BOULOS RAMIZ; FEUTRILL JOHN
权利人:BOULOS & COOPER PHARMACEUTICALS PTY LTD
摘要:A method for the synthesis of a aryl compound of Formula (1).n nU T-W—R 1 ) n    (1)

专利号:WO-9419366-A1
优先权日:1993-02-26
标题 :Chemical synthesis of squalamine
发明人：MORIARTY ROBERT M; GUO LIANG; TULADHAR SUDERSAN M
权利人:MAGAININ PHARMA
摘要:Methods for the chemical preparation or synthesis of the sterol antibiotic squalamine. Preferably, the preparation is by modifying the 3-position of a 3-oxo-7α-hydroxy-24z-ether protected alcohol group-5α-cholestane with a spermidino moiety to form a 3β-spermidino-7α-hydroxy-24z-ether protected group -5α-cholestane; deprotecting the 24-position of the 3β-spermidino-7α-hydroxy-24z-ether protected group-5α-cholestane to the free hydroxyl; and sulfating the 24-position of the 3β-spermidino-7α, 24-dihydroxy-5α-cholestane.

专利号:US-3742080-A
优先权日:1969-04-11
标 题 :Rhodium based catalysts for the synthesis of 1,4-dienes
发明人：SU A
权利人:DU PONT
摘要:Improved catalysts are provided for the synthesis of 1,4-dienes from Alpha -monoolefins and conjugated dienes. The catalysts are rhodium (III) salts in combination with amides, phosphoramides, phosphine oxides, or water. The improved catalysts allow control of the trans-cis ratio of the 1,4-diene formed and are operable at useful rates in a wide range of solvent systems, both protonic and aprotic.

专利号:US-9695188-B2
优先权日:2013-12-06
标 题 :Methods useful in the synthesis of halichondrin B analogs
发明人：HU YONGBO; ZHANG HUIMING; CHIBA HIROYUKI; KOMATSU YUKI; LEWIS BRYAN M
权利人:EISAI R&D MAN CO LTD
摘要:In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

专利号:US-11655158-B2
优先权日:2019-10-14
标题 :Isomorphous substitution of metals during the synthesis of a zeolite framework
发明人：MINTOVA Svetlana; GILSON JEAN-PIERRE; NESTERENKO NIKOLAI; MINOUX DELPHINE; AQUINO CINDY; GRAND JULIEN; DUBRAY FLORENT
权利人:TOTALENERGIES ONETECH; CENTRE NAT RECH SCIENT
摘要:The present disclosure relates to a novel staged-synthesis method for introduction of various metals in the structure of zeolite frameworks by isomorphous substitution. This new method is based on a hydrothermal synthesis in which the metal addition to the precursor suspensions (gel) is delayed. This so-called “staged-synthesis methodâ€? allows to obtain nanosized silanol highly homo-geneous crystalline zeolite structures with a control of the metal location.

专利号:US-8202985-B2
优先权日:2005-10-31
标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection
发明人：DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H
权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO
摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.