CAS: 623-91-6; Diethyl Fumarate

相似化合物

141-05-9 141-05-9 110-17-8

上下游产品

CAS号623-73-4 重氮乙酸乙酯 | CAS号64-17-5 乙醇 | CAS号110-17-8 富马酸,反丁烯二酸 | CAS号1114-31-4 diethyl meso-1,... | CAS号140-88-5 丙烯酸乙酯 | CAS号608-82-2 diethyl 2,3-dib... | CAS号1114-30-3 diethyl 2,3-dib... | CAS号623-50-7 乙醇酸乙酯 | CAS号1099-45-2 乙基(三苯基膦)乙酸酯 | CAS号292638-84-7 phenylene-ethylene | CAS号10302-94-0 (Z)-2-氯-2-丁烯二酸二乙酯 | CAS号710-43-0 顺式-环丙烷-1,2-二羧酸二乙酯 | CAS号3999-55-1 反式-1,2-环丙烷二甲酸二乙酯 | CAS号3588-17-8 反式,反式-1,3-丁二烯-1... | CAS号4753-29-1 2-(1-硝基乙基)琥珀酸二乙酯 | CAS号6345-08-0 2-(苄基氨基)-2-氧代乙酸 | CAS号100-46-9 苄胺 | CAS号142009-34-5 diethyl 2-bromo... | CAS号923-42-2 1,2,4-丁烷三羧酸 | CAS号110-15-6 琥珀酸； 丁二酸

L-(+)-酒石酸二乙酯置于ammonium Molybdate,Sodium Sulfite体系中,用 甲苯 作为反应溶剂,以20%的收率获得产物富马酸二乙酯
参考文献:使用商业催化剂和现成的还原剂进行脱氧
标题:使用商业催化剂和现成的还原剂进行脱氧
摘要:摘要 我们探索了使用市售钼化合物七钼酸铵 (Ahm) 在催化脱氧 (Dodh) 反应中使用亚硫酸钠 (Na2So3) 作为还原剂的用途.催化反应在相对较低的温度(170-190oc)下进行,以中等产率产生烯烃.
DOI:10.1016/j.Inoche.2018.11.015

专利信息

专利号:US-9193691-B2
优先权日:2012-04-27
标题:Methods for the synthesis of activated ethylfumarates and their use as intermediates
发明人：KRAFT KELLY SULLIVAN; FREEMAN JOHN J; SERWINSKI PAUL; PAVIA VINNIE; PHANSTIEL OTTO; KAUR NAVNEET
权利人:MANNKIND CORP; MANNKIND CORP
摘要:Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphosphoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

专利号:WO-2004037772-A1
优先权日:2002-10-22
标 题 :Convenient and scalable synthesis of ethyl n-[(2-boc-amino) ethyl] glycinate and its hydrochloride salt
发明人：HUDSON ROBERT H E; VIIRRE RUSSELL D
权利人:UNIV WESTERN ONTARIO; HUDSON ROBERT H E; VIIRRE RUSSELL D
摘要:The present invention discloses an improved synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride salt. The synthesis is based on the reductive alkylation of Boc-ethylenediamine with ethyl glyoxylate hydrate and furnishes the title compound in near quantitative yield and high purity without chromatography. This compound is suitable, as is, for the synthesis peptide nucleic acid monomers. Further, conversion to the hydrochloride salt provides a stable, non-hygroscopic solid that is a convenient form for handling and storage.

专利号:US-8273887-B2
优先权日:2008-09-30
标题:Processes for synthesis of opiate alkaloid derivatives
发明人：MANNINO ANTHONY; ZDRODOWSKI JAMES
权利人:MANNINO ANTHONY; ZDRODOWSKI JAMES; MALLINCKRODT LLC
摘要:The present invention provides processes for the synthesis of opiate alkaloids. In particular, the opiate alkaloids produced by the process of the invention are typically intermediate compounds that may be utilized to produce a variety of biologically active alkaloids including buprenorphine and diprenorphine.

专利号:US-6509506-B1
优先权日:1997-05-21
标 题 :Two step synthesis of D- and L- α-amino acids and D- and L- α-amino aldehydes
发明人：SHARPLESS K BARRY; LI GUIGEN
权利人:SCRIPPS RESEARCH INST
摘要:D- and L- α-amino acids and D- and L-α-amino aldehydes are synthesized from olefin substrates in two steps. The first step is a catalyzed asymmetric aminohydroxylation addition reaction to the olefin substrate. The addition reaction is catalyzed by osmium and is co-catalyzed by chiral ligands. The chiral ligands, in addition to being co-catalysts with the osmium, also serve to direct the addition reaction regioselectively and enantioselectively, divalent ligands are preferred over monovalent ligands because of their enhanced regio-and enantio-selectivity. As an oxidant nitrogen source for the addition reaction, either a carbamate or sulfonamide may be employed. If carbamate is employed as an oxidant nitrogen source, the resultant β-hydoxycarbamate is deprotected to yield the corresponding β-hydroxyamine. If sulfonamide is employed as an oxidant nitrogen source, the resultant β-hydroxysulfonamide is deprotected to yield the corresponding β-hydroxyamine. The resultant β-hydroxyamine is then selectively oxidized in a second synthetic step to produce the desired D- and L- α-amino acid or D- and L-α-amino aldehyde.

专利号:US-9365874-B2
优先权日:2007-08-10
标 题 :Methods for synthesis of olefins and derivatives
发明人：BURK MARK J; PHARKYA PRITI; VAN DIEN STEPHEN J; BURGARD ANTHONY P; SCHILLING CHRISTOPHE H
权利人:GENOMATICA INC
摘要:The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.

专利号:US-7417142-B2
优先权日:2002-03-28
标 题:Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same
发明人：ZHANG X PETER; CHEN YING; GAO GUANG-YAO
权利人:UNIV TENNESSEE RES FOUNDATION
摘要:Novel methods of synthesizing heteroatom-containing chiral porphyrins and chiral metalloporphyrins and the novel chiral porphyrins and chiral metalloporphyrins themselves are disclosed. Metal complexes of the chiral porphyrins are prepared in high yields and shown to be active catalysts for highly enantioselective and diastereoselective cyclopropanation, aziridination, and epoxidation of alkenes under a practical one-pot protocol.