CAS: 61315-59-1; Boc-D-Met-Oh (Dicyclohexylammonium) Salt
该化合物是一种该化合物是一种带有甲硫磷侧链的受保护氨基酸衍生物,可用于peptide合成和不对称变异.三丁氧基碳基(Boc)组确保正向保护,而硫醚功能允许进一步修改.两种化合物由于具有固定的立体化学特性和功能多功能,在制药和精细化学应用方面都很有价值.
相似化合物
27494-47-9 15098-69-8 22823-50-3MSDS等安全信息
合成工艺路线路线简述
📜二环己胺,N-Boc-D-蛋氨酸置于amine,Petroleum Ether,Ice,甲醇体系中,用 乙酸乙酯 作为反应溶剂,化学反应 2.0H,反应生成 叔丁氧羰基-D-蛋氨酸二环己胺盐
参考文献:Process For 4-(D-3-Amino-3-Carboxypropoxy)-Phenylglyoxylic Acid Oxime
标题:Process For 4-(D-3-Amino-3-Carboxypropoxy)-Phenylglyoxylic Acid Oxime
摘要:制备4-(D-3-氨基-3-羧基丙氧基)苯乙酰基肟的方法包括:用烷基或苯基碘化物烷基化氨基保护的d-蛋氨酸硅酯酯;将烷基磺鎓碘化物环化为氨基保护的d-脯氨酸内酯;在水性碱中水解内酯为氨基保护的d-脯氨酸;将氨基保护的d-脯氨酸以酯的形式与4-羟基苯乙酰基酸酯形成醚键;或将d-脯氨酸酯与保护氧肟化的酯化4-羟基苯乙酰基酸酯偶联,从而形成该醚的肟.该产品在制备抗生素fr 1923方面有用.
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
