CAS: 603-61-2; 3,5,7-Trihydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-4H-Chromen-4-One

上下游产品

2-benzoyloxy-1-(2,4,6-trihydroxy-phenyl)-ethanone 3,5,7,3'-tetrahydroxy-4'-methoxyflavanone 3,4'-O-dimethylquercetin quercetol3,5,7-triethoxy-2-(3-ethoxy-4-methoxy-phenyl)-chromen-4-one quercetol 16H10O13S2(2-)*2K(1+)C16H10O13S2(2-)*2K(1+) 16H9O16S3(3-)*3K(1+)C16H9O16S3(3-)*3K(1+)

📜(S)-2,3-Dihydro-5,7-Dihydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-4-Benzopyrone置于吡啶,Oxone||potassium Monopersulfate Triple Salt,Palladium 10% On Activated Carbon,氢气,碘,碳酸氢钠,Sodium Carbonate,Potassium Carbonate体系中,用 丙酮 作为反应溶剂,化学反应生成 柽柳黄素
参考文献:黄酮苷的半合成及其对三阴性乳腺癌的抗炎和抗肿瘤活性
标题:黄酮苷的半合成及其对三阴性乳腺癌的抗炎和抗肿瘤活性
摘要:背景:已知类黄酮苷具有多种生物活性,包括抗肿瘤和抗炎特性.橙皮素在自然界中含量丰富,可用于合成具有生物活性的黄酮类化合物.具有成本低,合成步骤短,操作简单,收率高等优点.目的:在本研究中,我们旨在从橙皮素中合成具有生物活性的类黄酮和类黄酮苷,并评估这些化合物的抗肿瘤和抗炎活性.方法: 采用甲氧基化,氧化脱氢,苄基化,脱苄基,脱乙酰化以及改良的过氧丙酮法和糖苷缩合反应合成了一系列黄酮类化合物及其衍生物.评估了它们对 Lps 诱导的 Raw264.7 小鼠巨噬细胞中一氧化氮 (No),肿瘤坏死因子 (Tnf-α) 和白细胞介素 6 (Il-6) 产生的抑制作用的抗炎活性.它们的结构通过 Hrms,1 H-NMR 和13 C-NMR 表征,并通过使用 Mst 测定法测试了它们对人三阴性乳腺癌细胞 (Tnbc) 细胞系 Sum 149 的细胞毒性.结果:大多数化合物在测试浓度下以剂量依赖性方式显着降低
DOI:10.1002/cbdv.202200899

专利信息

专利号:WO-2025081225-A1
优先权日:2023-10-17
标 题 :Synthesis of polyphenols
发明人：TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
权利人:Delica Therapeutics Pty Ltd
摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

专利号:US-2024026314-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
发明人：ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:EP-4251758-A1
优先权日:2020-11-25
标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds

专利号:WO-2022109736-A1
优先权日:2020-11-25
标题:Polypeptides for use in the synthesis of bioactive phenolic compounds

专利号:CA-3202377-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds