专利号:US-5514830-A 优先权日:1991-07-25 标题 :Process for producing nitrile 发明人:OKU MASAYUKI; FUJIKURA YOSHIAKI 权利人:KAO CORP 摘要:The present invention provides a process for producing a nitrile represented by the general formula (1): RC=N(1) wherein R is alkyl, alkenyl, aralkyl or aryl, each may have a substituent, characterized by heating an aldoxime represented by the general formula (2): RCH=NOH(2) wherein R is as defined above, in the presence of one or more catalysts selected from hydroxides of alkali metals, alcoholates of alkali metals, hydroxides of alkaline earth metals and alcoholates of alkaline earth metals, and distilling off water formed in the course of the reaction from the reaction system. The process according to the present invention can produce a nitrile which is useful as a perfume or as a starting material for the organic synthesis of perfumes, medicines and so on in high yields and advantageously from the viewpoint of production economy.
专利号:US-12076423-B2 优先权日:2015-12-23 标题 :Spiculisporic acid-based composition 发明人:AGNAOU REDA; MARION CATHERINE 权利人:OREAL 摘要:Composition in the form of an oil-in-water emulsion that includes at least 1% of an oil phase, and an aqueous phase. The composition includes 0.1 to 15 wt % spiculisporic acid relative to the total weight of the composition, at least one base selected from amino acids and alkanolamines in an amount suitable for forming at least a monosalt of spiculisporic acid, less than 3% glycol(s) and/or polyol(s) relative to the total weight of the composition, at least one UV filter and/or an additive selected from volatile aromatic materials such as essential oils and fragrance substances, fillers, dyeing materials such as pigments, mother-of-pearl or particles with a metallic sheen, moisturizers, anti-wrinkle or anti-age agents, peeling agents, antioxidants, active ingredients stimulating the synthesis of epidermal and/or dermal macromolecules, dermo-relaxing agents, depigmentation agents, deodorant agents and mixtures thereof.
专利号:EP-0550762-B1 优先权日:1991-07-25 标 题 :Process for producing nitrile 发明人:OKU MASAYUKI; FUJIKURA YOSHIAKI 权利人:KAO CORP 摘要:A process for producing a nitrile represented by the general formula (1): RC = N wherein R represents alkyl, alkenyl, aralkyl or aryl each of which may be substituted, by heating an aldoxime represented by the general formula (2): RCH = NOH wherein R is as defined above, in the presence of at least one catalyst selected among hydroxides and alcoholates of alkali metals and alkaline earth metals, and distilling off water formed in the course of the reaction from the reaction system. The process enables nitriles useful as the starting material for the organic synthesis of perfumes, medicines and so forth to be produced in high yields at a remarkably reduced production cost.
专利号:US-8349790-B2 优先权日:2007-10-29 标 题:Substituted octane(ene) nitriles, methods for the synthesis thereof and uses thereof in perfumery 发明人:MANE JEAN; CLINET JEAN-CLAUDE 权利人:MANE FILS V; MANE JEAN; CLINET JEAN-CLAUDE 摘要:Compounds of general formula (I) below: in which R is a hydrogen atom, a methyl group, a CH2OH group, an ester group, preferably COOEt, or a methylene group, and in which not more than one of the four dashed lines represents a carbon-carbon double bond, and also their enantiomers and their diastereoisomers, a process for preparing them, and their use as an odorant agent in perfuming compositions.
专利号:EP-2840077-A1 优先权日:2013-08-20 标 题:Process for the manufacture of hydrogenated nitriles 发明人:BEUMER RAPHAEL; BONRATH WERNER; LEHMANN HAJO; MEDLOCK JONATHAN ALAN 权利人:DSM IP ASSETS BV 摘要:The present invention relates to the manufacture and the use of specific organic compounds of formula (II)n nwherein n is either 1 or 2, and wherein R 1 is linear C 1-4 alkyl or branched C 3-4 alkyl, wherein R 2 is hydrogen or linear C 1-4 alkyl or branched C 3-4 alkyl, as aroma ingredients in flavors and fragrances. Furthermore the invention relates to new specific organic compounds and their synthesis, as well as to flavor and fragrance formulations comprising at least one of the specific organic compounds.
专利号:BE-866404-A 优先权日:1977-04-26 标题:PROCESS FOR THE SYNTHESIS OF DINITRILS, PRODUCTS THUS OBTAINED AND THEIR DERIVATIVES
[参考文献]: S Chen, Et Al. Blocking Adenylyl Cyclase Inhibits Olfactory Generator Currents Induced By "Ip(3)-Odors". J Neurophysiol. 2000 Jul;84(1):575-80.
合成参考文献
摘要:Dornan, L. M.; Hughes, N. L.; Muldoon, M. J., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 549. 摘要:Food and Cosmetics Toxicology., 14(787), 1976