CAS: 496-65-1; (R)-2,4-Dihydroxy-N-(3-((2-Mercaptoethyl)Amino)-3-Oxopropyl)-3,3-Dimethylbutanamide

上下游产品

D-pantothenic acid-(2-benzylsulfanyl-ethylamide) β-alanine-(2-mercapto-ethylamide) (R)-Pantolacton D-pantethine D-pantethine N-D-pantoyl-β-alanine-(2-benzoylmercapto-ethylamide)N-D-pantoyl-β-alanine-(2-benzoylmercapto-ethylamide) (5R,6R)-3-{2-[3-((R)-2,4-Dihydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethylsulfanyl}-6-ethyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester D‐pantetheine 4'‐phosphate

📜(R)-3-(2,2,5,5-Tetramethyl-1,3-Dioxane-4-Carboxamido)Propanoic Acid置于盐酸,1-(3-二甲基氨基丙基)-3-乙基碳二亚胺,三乙胺,N,N-二异丙基乙胺体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 2.17H,反应生成 泛硫醇
参考文献:One-Pot Chemo-Enzymatic Synthesis Of Reporter-Modified Proteins
标题:One-Pot Chemo-Enzymatic Synthesis Of Reporter-Modified Proteins
摘要:为了应对蛋白质共价报告标记领域的最新进展,我们提出了一种灵活的报告模拟物合成方法.在此,我们展示了一种一锅法化学酶合成带有报告标记的蛋白质的技术,该技术能够在载体蛋白质或融合构建体上共价连接任何氨基末端荧光或亲和标记.这一双反应序列包括活化的泛酸结合,生物合成转化为辅酶a(coa)模拟物,以及通过磷酸泛酰巯基乙胺转移酶(pptase)进行的载体蛋白质修饰.我们还探究了该途径中第一个酶coaa的底物特异性.通过这种方法,Coa模拟物可以迅速制备,从而允许各种分子种类的报告基团在特定位置进行连接.
DOI:10.1039/b512735A

专利信息

专利号:WO-2012017400-A1
优先权日:2010-08-03
标 题 :Synthesis of acyl-pantetheine derivatives and the use thereof in the synthesis of acyl-coenzyme a derivatives
发明人：VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS
权利人:UNIV NORTHWEST; VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS
摘要:The present invention relates to a novel synthesis method for acyl-pantetheine derivatives. The present invention further relates to the use of said synthesized acyl-pantetheine derivatives as a starting material in the enzymatic synthesis of acyl-coenzyme A derivatives. According to a first aspect thereof, the present invention provides a method for the synthesis of acyl-pantetheine derivatives, the method including the steps of: a) providing a source of pantetheine; b) providing a source of acyl ester; and c) contacting the source of pantetheine with the source of acyl ester to form the corresponding acyl-pantetheine derivative, having the general formula (I), wherein R is an acyl group.The present invention also provides a method for the synthesis of acyl-coenzyme A derivatives as well as the use of a source of pantetheine and a source of acyl ester in the preparation steps of these two methods.

专利号:US-5043328-A
优先权日:1986-05-09
标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
发明人：WEITHMANN KLAUS U
权利人:HOECHST AG
摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

专利号:US-9963472-B2
优先权日:2013-11-04
标 题 :Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (PKAN) and methods for the synthesis of such compounds
发明人：JENKO BRANKO; KOSEC GREGOR; PETKOVIC HRVOJE; PODGORSEK BERKE AJDA; PAHOR JERCA; CUSAK ALEN; SIBON ODA CORNELIA MARIA; SRINIVASAN BALAJI
权利人:ACIES BIO D O O; UNIV GRONINGEN; ACADEMISCH ZIEKENHUIS GRONINGEN
摘要:The invention relates to (S)-acyl-4′-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.

专利号:US-5662898-A
优先权日:1990-08-20
标 题 :Genes for the synthesis of antipathogenic substances
发明人：LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E
权利人:CIBA GEIGY CORP
摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

专利号:US-6600029-B1
优先权日:1995-12-19
标题:Metabolic engineering of polyhydroxyalkanoate monomer synthases
发明人：SHERMAN DAVID H; WILLIAMS MARK D; XUE YONGQUAN
权利人:UNIV MINNESOTA
摘要:A novel pathway for the synthesis of polyhydroxyalkanoate is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalknoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalknoate synthase.

专利号:US-2022162188-A1
优先权日:2019-01-15
标 题:Isoprenoids and methods of making thereof
发明人：WILLIAMS GAVIN; LUND SEAN; HALL RACHAEL
权利人:UNIV NORTH CAROLINA STATE
摘要:Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.