CAS: 474-86-2; Equilin

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CAS号6733-79-5 3-methoxyestra-... | CAS号3563-27-7 雌甾-1,3,5(10),7-... | CAS号1425-10-1 19-去甲睾酮乙酸盐 | CAS号2590-41-2 脱氢诺龙醋酸酯 | CAS号6925-84-4 3-Ethoxy-17β-ac... | CAS号13587-56-9 3-methoxy-1,3,5... | CAS号23961-02-6 3-methoxy-17β-f... | CAS号474-87-3 Δ8,9-脱氢雌酮 | CAS号3563-27-7 雌甾-1,3,5(10),7-... | CAS号53-16-7 雌酚酮 | CAS号517-09-9 马萘雌甾酮 | CAS号791-69-5 Δ9,11-雌二醇-d3 | CAS号651-55-8 α-Equilol | CAS号16680-47-0 Estra-1,3,5(10)...

📜在 盐酸,Potassium Carbonate体系中,用 甲醇,水 作为反应溶剂,化学反应 1.5H,以90%的收率获得产物马烯雌酮
参考文献:一种合成马烯雌酮的方法
标题:一种合成马烯雌酮的方法
摘要:本发明是一种甾体药物马烯雌酮的合成方法.本方法从雌酚酮出发,经酚羟基以及c17位缩酮保护后,再经氧化并进一步脱氢得中间体ii;还原脱氧后得中间体iii;最后脱保护得最终产物马烯雌酮原料药.该方法步骤经济,共四步转化;总收率高达50%;原料相对廉价易得,整条工艺路线绿色安全,原料药质量高,纯度可达99.8%及以上,适宜工业化生产.

专利信息

专利号:US-5567830-A
优先权日:1994-02-14
标题 :Process for synthesis of acetylenic carbinols
发明人：UPASANI RAVINDRA B
权利人:COCENSYS INC
摘要:A method for the preparation of an acetylenic alcohol by reaction of 1,2-dibromoethylene with an alkyl, aryl an heteroaryl lithium in an inert solvent, followed by reaction with a carbonyl-containing compound to give an acetylenic alcohol is disclosed.

专利号:US-5449795-A
优先权日:1994-02-14
标 题 :Process for synthesis of steroidal allylic tert. alcohols
发明人：HOGENKAMP DERK J
权利人:COCENSYS INC
摘要:A method for the preparation of a steroidal allylic tertiary alcohol is disclosed which involves the deprotonation of a sulfoxide with a strong base which is capable of deprotonating the methine proton which is α to the sulfoxide, in an inert solvent to give the anion; reaction of the anion with a steroidal spiro-2'-oxirane to give a steroidal γ-hydroxysulfoxide; and thermolysis in the presence of a base other than calcium carbonate to give the steroidal allylic tertiary alcohol.

专利号:US-3555015-A
优先权日:1968-09-17
标 题 :Process for the preparation of gona-1,3,5(10),7-tetraenes
发明人：STEIN REINHARDT P; BUZEY GEORGE C JR; SMITH HERCHEL
权利人:AMERICAN HOME PROD
摘要:TREATMENT OF A 13-ALKYLGONA-1,3,5(10),8-TETRAENE WITH ORGANIC PERACID RESULTS IN THE FORMATION OF A CORRESPONDING 8,9-EPOXY-13-ALKYLGONA-1,3,5(10)-TRIENE, WHICH UPON TREATMENT WITH ACID, IS RING-OPENED AND REARRANGED TO THE CORRESPONDING 13-ALKYLGONA-1,3,5(10),9(11)-TETRAEN-8-OL. CATALYTIC HYDROGENATION THEN AFFORDS THE CORRESPONDING 13-ALKYLGONA-1,3,5(10)-TRIEN-8-OL WHICH UPON DEHYDRATION GIVES THE CORRESPONDING 13-ALKYLGONA-1,3,5(10),7-TETRAENE. THERE IS THUS PROVIDED A ROUTE TO THE SYNTHESIS OF EQUILIN AND RELATED COMPOUNDS.

专利号:US-7105637-B2
优先权日:2002-02-15
标题 :Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), methods of their synthesis
发明人：SHACKLETON CEDRIC; GUO LI-WEI; WILSON WILLIAM K
权利人:CHILDRENS HOSP & RES CT OAK
摘要:The invention provides isolated dehydro-estriol (8-DHE 3 ) and dehydro-pregnanetriol (7-DHPT), and methods of their synthesis. These compounds are useful in diagnosis of Smith-Lemli-Optiz syndrome (SLOS).

专利号:US-2013261317-A1
优先权日:2010-09-27
标题 :Methods for preparing synthetic bile acids and compositions comprising the same
发明人：MORIARTY ROBERT M; RAO PHOTON
权利人:MORIARTY ROBERT M; RAO PHOTON; KYTHERA BIOPHARMACEUTICALS INC
摘要:This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C 14 population than naturally occurring bile acids as well as being free from any mammalian pathogens. This invention is also directed to the synthesis of intermediates useful in the synthesis of such bile acids. Accordingly, the C ring of the steroidal scaffold is oxidized to provide a synthetic route and intermediates to DCA. This invention also provides synthetic methods for preparing deoxycholic acid or a salt thereof starting from aromatic steroids such as estrogen, equilenin, and derivatives thereof. This invention is also directed to intermediates such as 12-oxo or delta-9,11-ene steroids as well as novel processes for their preparation. In preferred embodiments, bile acids are provided herein which have substituents on the B-ring and/or D-ring side chain and optionally on the hydroxy group of the A-ring.

专利号:EP-0354945-B1
优先权日:1988-01-13
标 题 :Process for the enhancement of enzyme activities and synthetic efficiency in microorganisms and higher plants
发明人：FIEDLER FRANZ; ZENK MEINHART H; GUNDLACH HEIDRUN; WEBER ALFRED; KENNECKE MARIO
权利人:SCHERING AG
摘要:In the process disclosed, the organisms are brought into contact witn inactivated elicitor-containing microorganisms, fragments of the latter, or excretions of elicitor-containing microorganisms. Only inactivated elicitor-containing bacteria, fragments of the latter, or excretions of elicitor-containing bacteria may be used to activate enzymes and promote synthesis in non-microbial organisms. The process can be used, for example, to promote synthesis in microorganisms or plants which produce pigments, antibiotics, alkaloids or phytoalexins or to activate enzymes in microorganisms capable of transforming steroids.