CAS: 35905-85-2; 2-Bromonicotinic Acid

相似化合物

128071-75-0 20577-26-8 131747-54-1

上下游产品

CAS号3430-17-9 2-溴-3-甲基吡啶 | CAS号128071-75-0 2-溴-3-吡啶甲醛 | CAS号109-04-6 2-溴吡啶 | CAS号1603-40-3 2-氨基-3-甲基吡啶 | CAS号124-38-9 二氧化碳 | CAS号87674-18-8 2-溴烟碱 | CAS号609-71-2 2-羟基烟酸 | CAS号67367-26-4 2-甲氧基烟酸甲酯 | CAS号101419-78-7 2-(4-氟苯基)烟酸 | CAS号100872-65-9 2-(benzylcarbam... | CAS号128071-75-0 2-溴-3-吡啶甲醛 | CAS号131747-54-1 2-溴-3-吡啶甲醇 | CAS号116026-98-3 2-溴-3-(B°C-氨基)吡啶 | CAS号116026-99-4 (2-甲酰基吡啶-3-基)氨基甲酸叔丁酯 | CAS号932042-98-3 2-bromo-3-ethen...

2-溴-3-吡啶甲醛置于potassium Permanganate体系中,用 水 用作溶剂,以100%的收率获得2-溴烟酸
参考文献:基于芳族金属化的合成策略-交叉偶联链节.氮杂菲生物碱紫杉胺的简明形式合成
标题:基于芳族金属化的合成策略-交叉偶联链节.氮杂菲生物碱紫杉胺的简明形式合成
摘要:使用组合金属化(邻位和远程)-交叉偶联策略,可以有效地合成预先转化成紫杉胺(10)的氮杂菲蒽醌9.
Doi:10.1016/s0040-4039(00)93486-5

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:WO-2010096722-A1
优先权日:2009-02-20
标 题 :3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors
发明人：FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
权利人:TAKEDA PHARMACEUTICAL; FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG
摘要:Claimed are intermediates in the synthesis of N-Arylmethyl-3-Oxo-2,3-dihydro- [1,2,4]triazolo[4,3-a]pyridine-6-carboxamides as well as a process (A) to arrive at 3-Oxo-2, 3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid. The triazolo[4,3-a]pyridine-6-carboxamides of formula (I) are used as soluble epoxide hydrolase inhibitors (sEH) having therapeutic effect in pathologic conditions such as hypertension, stroke, inflammatory processes, diabetes and a variety of cardiovascular diseases.

专利号:EP-0789577-A1
优先权日:1995-06-07
标 题:Synthesis of n-substituted oligomers

专利号:JP-3943593-B2
优先权日:1995-06-07
标题:Synthesis of N-substituted oligomers

专利号:JP-2006182780-A
优先权日:1995-06-07
标 题 :Synthesis of N-substituted oligomers

专利号:EP-0789577-B1
优先权日:1995-06-07
标 题:Synthesis of n-substituted oligomers