CAS: 309956-78-3; (R)-Tert-Butyl Piperidin-3-Ylcarbamate

相似化合物

127294-77-3 138060-07-8 168466-84-0

上下游产品

CAS号485820-12-0 (R)-苯甲基 3-((叔-丁... | CAS号1189160-63-1 t-butyl (R)-pip... | CAS号454713-13-4 (S)-1-苄基-3-N-叔丁... | CAS号485820-12-0 (R)-苯甲基 3-((叔-丁... | CAS号454713-13-4 (S)-1-苄基-3-N-叔丁...

D-谷氨酸置于ammonium Hydroxide,Sodium Tetrahydroborate,氯化亚砜,乙醇,三乙胺体系中,用 二氯甲烷,乙腈 用作溶剂,化学反应 56.5H,反应生成(R)-3-Boc-氨基哌啶
参考文献:(R)-3-氨基哌啶双盐酸盐的制备方法
标题:(R)-3-氨基哌啶双盐酸盐的制备方法
摘要:本发明公开了一种(R)-3-氨基哌啶双盐酸盐的制备方法,D-谷氨酸为起始原料,经过①羟基酯化和胺基boc保护,②酯基还原,③羟基活化,④环化,⑤胺基脱boc保护,五步反应,得到(R)-3-氨基哌啶双盐酸盐.本发明的制备方法合成路线短,成本低,可实现工业化生产.

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:CA-2743700-C
优先权日:2008-12-15
标题 :Stereoselective synthesis of piperidine derivatives

专利号:EP-2376477-A2
优先权日:2008-12-15
标 题 :Stereoselective synthesis of piperidine derivatives

专利号:CN-110872292-A
优先权日:2019-11-30
标题 :A route to the synthesis of the diabetes drug linagliptin

专利号:CN-102093260-A
优先权日:2009-12-14
标 题:Stereospecific Synthesis of Piperidine Derivatives

专利号:WO-2010077798-A2
优先权日:2008-12-15
标 题 :Stereoselective synthesis of piperidine derivatives