CAS: 2756-87-8; (E)-4-Methoxy-4-Oxobut-2-Enoic Acid

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141-05-9 623-91-6 624-48-6

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CAS号3052-50-4 马来酸单甲酯 | CAS号624-49-7 富马酸二甲酯 | CAS号108-31-6 顺酐 | CAS号623-43-8 巴豆酸甲酯 | CAS号67-56-1 甲醇 | CAS号110-17-8 富马酸,反丁烯二酸 | CAS号17081-97-9 methyl 4-chloro... | CAS号5837-72-9 富马醛酸甲酯 | CAS号57314-32-6 Maleinaldehydsa... | CAS号2459-05-4 富马酸单乙酯 | CAS号2987-87-3 2-Butenoic acid... | CAS号6270-74-2 3-氧代-3,4-二氢-2H-... | CAS号7556-63-0 甲基[2H-1,4-苯并噻嗪-... | CAS号33176-41-9 2-(2-氨基-4-氧代-1,... | CAS号17081-97-9 methyl 4-chloro...

巴豆酸甲酯置于叔丁基过氧化氢,[rh2(Cap)4*2Ch3Cn]体系中,用 水,1,2-二氯乙烷 用作溶剂,化学反应 40.0H,以32%的收率获得富马酸单甲酯
参考文献:己内酰胺二铑通过水性叔丁基过氧化氢催化烯丙基氧化:叔丁基过氧自由基的作用
标题:己内酰胺二铑通过水性叔丁基过氧化氢催化烯丙基氧化:叔丁基过氧自由基的作用
摘要:Dirhodium (II) 己内酰胺在生成叔丁基过氧自由基方面表现出最佳效率,叔丁基过氧自由基是氢原子提取的选择性试剂.这些氧化反应发生在叔水溶液中-丁基氢过氧化物 (Tbhp) 没有快速水解二铑上的己内酰胺配体.烯酮的烯丙基氧化以中等至高产率产生相应的烯二酮,其应用包括甾体烯酮的烯丙基氧化.虽然亚甲基氧化成酮更有效,但也可以实现甲基氧化成羧酸.在与其他金属催化剂的比较研究中描述了己内酰胺二铑 (II) 作为 Tbhp 烯丙基氧化的催化剂的优越效率(催化剂的摩尔%,转化率).不同的催化剂以相同的相对产率产生基本上相同的产物混合物表明催化剂不参与产物形成步骤.烯酮烯丙基氧化研究产生的机理影响为控制产物形成的因素提供了新的见解.以前未公开的歧化途径,由已发现混合过氧化物的叔丁氧基自由基,用于通过烯丙基氧化形成酮产物.
Doi:10.1021/jo8021132

专利信息

专利号:WO-2017046598-A1
优先权日:2015-09-16
标题:Treatment of acute inflammatory disorders
发明人：CRISANTI ANDREA; CANAVESE MIRIAM
权利人:CRISANTI ANDREA; IMP INNOVATIONS LTD
摘要:The present invention relates to a VEGF receptor agonist for use in the treatment of an acute inflammatory disorder associated with the overproduction of pro-inflammatory cytokine, administered with an agent that induces the synthesis of Nrf2. The invention also relates to pharmaceutical combinations comprising a VEGF receptor agonist and an agent that induces the synthesis of Nrf2, and kits comprising these agents. The described uses, combinations and methods may prevent or reduce the dis-regulated activation of an inflammatory response and reduce endothelial damage.

专利号:US-10336912-B2
优先权日:2014-08-01
标 题 :Methods for producing and using aqueous polyurethane/polyacrylate hybrid dispersions and use of said aqueous polyurethane/polyacrylate hybrid dispersions in coating agents
发明人：JAHNS EKKEHARD; MANGEL TIMO; ROESCH CHRISTINE; ROMANATO PAOLA; BURK YENI; PAKUSCH JOACHIM
权利人:BASF SE
摘要:The present invention provides an aqueous polyurethane (PU)-polyacrylate hybrid dispersion obtainable by free radical polymerization of at least one acrylate polymer (A1) in the presence of at least one polyurethane (P1), a process for preparing these aqueous polyurethane-polyacrylate hybrid dispersions, wherein said process comprises a) preparing an aqueous polyurethane dispersion and b) using the polyurethane dispersion thus prepared as raw material for the further synthesis of a polyacrylate dispersion, and the use of the hybrid dispersion thus obtained as binder in filled coating materials, particularly as a binder for flexible roof coatings.

专利号:WO-2023213264-A1
优先权日:2022-05-05
标 题 :Synthesis of amide compound and use thereof
发明人：WANG ZHAOYIN; ZHANG JIAN; CAO JINRUI
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:The present invention relates to a novel oleanamide derivative for activating a KEAP/NRF2/ARE signaling pathway. The compound of the present invention is represented by general formula (I), wherein L, R 3 , R 4 , Z, and n are set forth in the description specification and the claims. Also disclosed are a method for preparing the compound represented by general formula I and an activity test result thereof for activating the KEAP/NRF2/ARE signaling pathway. The compound represented by general formula (I) of the present invention can be used for treating and preventing multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia (FRDA), spinal muscular atrophy (SMA), neuromyelitis optica (NMO), spinocerebellar ataxia (SCA), and other neurodegenerative diseases, and can also be used for treating cerebral apoplexy, autoimmune diseases, diabetes, kidney diseases, and other chronic diseases.

专利号:US-10626076-B2
优先权日:2014-03-17
标题:Process for the synthesis of dimethyl fumarate
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN; RADHA NAGARAPU
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD; BIOPHORE INDIA PHARMAEUTICALS PVT LTD
摘要:The present invention describes an improved process for the industrial scale production of dimethyl fumarate. The process involves a one-pot ring opening reaction of maleic anhydride to monomethyl maleate and isomerization into the corresponding monomethyl fumarate in presence of a Lewis acid. Finally the mono methyl fumarate was converted into the dimethyl fumarate by an acid catalyzed esterification reaction.

专利号:US-6599972-B2
优先权日:1996-12-24
标 题 :Latex compositions containing ethylenically unsaturated esters of fatty compounds and applications thereof
发明人：THAMES SHELBY FRELAND; PANJNANI KAMLESH GOPICHAND; FRUCHEY OLAN STANLEY
权利人:UNIV SOUTHERN MISSISSIPPI
摘要:Novel latex or emulsion compositions containing internally plasticizing and crosslinkable monomers derived from traditional semi-drying or non-drying oils are disclosed and claimed. The monomers are ethylenically unsaturated derivatives of long-chain olefinic compounds. Preferred embodiments include latex formed from acrylate or methacrylate esters of fatty alcohols. A process for the synthesis of the latex composition is also disclosed, which involves (a) polymerization of the ethylenically unsaturated derivatives of a long-chain olefinic compound in an aqueous phase with at least one other copolymerizable monomer; and (b) blending of so formed polymer with at least one drier and a surfactant to form the novel latex or emulsion compositions. These compositions form films at low minimum film forming temperatures (MFT) ranging from -5 to 10° C. and cure to above ambient glass transition (Tg) polymers without the use of traditional organic cosolvents which contribute to environmental pollution via volatile organic compounds (VOCs) emissions. These compositions are therefore useful in waterborne coatings, contact and pressure sensitive adhesives, and inks.

专利号:US-5527613-A
优先权日:1992-04-10
标 题:Synthesis of latex capsules
发明人：BLANKENSHIP ROBERT M; NOVAK RONALD W; NEYHART CLARENCE J; VOGEL MARTIN
权利人:ROHM & HAAS
摘要:The present invention is concerned with core and shell polymeric particles having microvoids in the core and one or more channels connecting the microvoids to the exterior of the particle. These particles, or LCAPs are produced by forming a core of polymeric acid, encasing the core in a shell polymer permeable to base, and then neutralizing the core such that the core swells, causing the shell to 'explode' in a controlled fashion. This controlled explosion causes channels to form in the shell. n These particles can be used as control release devices for target compounds, to impart reinforcing properties to acrylic films, as an opacifying agent in coating compositions, and as a supplement or replacement of part or all of the pigmentary material or extenders that would otherwise be used in such coating compositions.