CAS: 1878-18-8; 1-​butanethiol, 2-​methyl

该化合物是有机化合物,其特性是附于一个环烷链的硫醇功能组(-SH),其分子式为C5H12S,具有一种独特而强的气味,通常被描述为kunky或类似大蒜.该化合物是一种无色液体,在室内温度下可溶于有机溶剂,但溶解于水中,溶解性有限.其沸点相对较低,允许其迅速蒸发. 2-M乙基-1-丁烷醇主要用于各种化学品的合成,并用作食品工业的调味剂,尽管其强味可能是一个限制因素.此外,它被用于某些药品的生产,并作为有机合成的中间体.由于它可能造成刺激,在与该化合物合作时,适当的处理和安全防范措施至关重要.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

1-bromo-2-methyl-butane 2-methyl-1-(phenylthio)butane 1-(2-methylbutylthio)-1-[(4-methylphenyl)sulfonyl]propane (E)-1-(2-methylbutylthio)-1-[(4-methylphenyl)sulfonyl]propene 1-chloro-1-(2-methylbutylthio)-1-[(4-methylphenyl)sulfonyl]propane

合成工艺路线路线简述

    1-溴-2-甲基丁烷置于sodium Thiosulfate体系中,化学反应生成2-甲基-1-丁硫醇
    参考文献:Obolenzew Et Al.,1957,# 10,P. 60,62
    标题:Obolenzew Et Al.,1957,# 10,P. 60,62

    海关参考信息

    专利信息


    专利号:US-2006167025-A1
    优先权日:2004-12-22
    标 题:Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
    发明人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
    权利人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
    摘要:The invention relates to tricyclic amino alcohols of general formula (I) n nmethod for synthesis of same and use of same as anti-inflammatory agents.

    专利号:US-10570114-B2
    优先权日:2016-05-19
    标题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling
    发明人:FISK JASON S; LI XIAOYONG; Muehlfeld Mark; BAUMAN ROBERT S; OPPENHEIMER JOSSIAN; TU SIYU; NITZ MARK A; CHAKRABARTI REETAM; FEIST SHAWN D; RINGER JAMES W; LENG RONALD B
    权利人:DOW AGROSCIENCES LLC
    摘要:Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.

    专利号:US-7329767-B2
    优先权日:2003-10-03
    标 题:Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
    发明人:DEWIS MARK L; JOHN THUMPLASSERIL V; ECKERT MARKUS A; COLSTEE JAN HERMAN; DA COSTA NEIL C; PEI TAO
    权利人:INT FLAVORS & FRAGRANCES INC
    摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formulan n nwherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

    专利号:US-8007841-B2
    优先权日:2003-10-03
    标 题 :Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
    发明人:JOHN THUMPLASSERIL V; ECKERT MARKUS A; DEWIS MARK L; COLSTEE JAN HERMAN; DA COSTA NEIL C
    权利人:INT FLAVORS & FRAGRANCES INC
    摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formula —(CH 2 ) n —, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

    专利号:US-2018334444-A1
    优先权日:2016-05-19
    标 题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling

    专利号:US-2023357155-A1
    优先权日:2020-03-18
    标 题:Improved synthesis of 4-amino-6-(heterocyclic)picolinates
    发明人:CANTURK BELGIN; DEVARAJ JAYACHANDRAN; HAZARI AMARUKA; KASSL CHRISTOPHER; LEE MELISSA; LI FANGZHENG; LOWE CHRISTIAN T; SIDDALL THOMAS L; WHITEKER GREGORY T; ZHANG CHUNMING
    权利人:CORTEVA AGRISCIENCE LLC
    摘要:The present disclosure relates to improved processes for preparing 4-amino-6-(heterocyclic)picolinates.
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    主要参考文献

    参考标题:Synthesis Of Alkenyl Sulfides Through The Iron-Catalyzed Cross-Coupling Reaction Of Vinyl Halides With Thiols
    作者:Yun-Yung Lin,Yu-Jen Wang,Che-Hung Lin,Jun-Hao Cheng,Chin-Fa Lee |发布日期:2012.7.20
    摘要:Here The Iron-Catalyzed Cross-Coupling Reaction Of Alkyl Vinyl Halides With Thiols. While Many Works Are Devoted To The Coupling Of Thiols With Alkyl Vinyl Iodides, Interestingly, The Known S-Vinylation Of Vinyl Bromides And Chlorides Is Limited To 1-(2-Bromovinyl)Benzene And 1-(2-Chlorovinyl)Benzene. Investigation On The Coupling Reaction Of Challenging Alkyl Vinyl Bromides And Chlorides With Thiols

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