专利号:US-2006167025-A1 优先权日:2004-12-22 标 题:Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs 发明人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID 权利人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID 摘要:The invention relates to tricyclic amino alcohols of general formula (I) n nmethod for synthesis of same and use of same as anti-inflammatory agents.
专利号:US-10570114-B2 优先权日:2016-05-19 标题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling 发明人:FISK JASON S; LI XIAOYONG; Muehlfeld Mark; BAUMAN ROBERT S; OPPENHEIMER JOSSIAN; TU SIYU; NITZ MARK A; CHAKRABARTI REETAM; FEIST SHAWN D; RINGER JAMES W; LENG RONALD B 权利人:DOW AGROSCIENCES LLC 摘要:Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.
专利号:US-7329767-B2 优先权日:2003-10-03 标 题:Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof 发明人:DEWIS MARK L; JOHN THUMPLASSERIL V; ECKERT MARKUS A; COLSTEE JAN HERMAN; DA COSTA NEIL C; PEI TAO 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formulan n nwherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
专利号:US-8007841-B2 优先权日:2003-10-03 标 题 :Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof 发明人:JOHN THUMPLASSERIL V; ECKERT MARKUS A; DEWIS MARK L; COLSTEE JAN HERMAN; DA COSTA NEIL C 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formula —(CH 2 ) n —, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
专利号:US-2018334444-A1 优先权日:2016-05-19 标 题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling
专利号:US-2023357155-A1 优先权日:2020-03-18 标 题:Improved synthesis of 4-amino-6-(heterocyclic)picolinates 发明人:CANTURK BELGIN; DEVARAJ JAYACHANDRAN; HAZARI AMARUKA; KASSL CHRISTOPHER; LEE MELISSA; LI FANGZHENG; LOWE CHRISTIAN T; SIDDALL THOMAS L; WHITEKER GREGORY T; ZHANG CHUNMING 权利人:CORTEVA AGRISCIENCE LLC 摘要:The present disclosure relates to improved processes for preparing 4-amino-6-(heterocyclic)picolinates.
参考标题:Synthesis Of Alkenyl Sulfides Through The Iron-Catalyzed Cross-Coupling Reaction Of Vinyl Halides With Thiols 作者:Yun-Yung Lin,Yu-Jen Wang,Che-Hung Lin,Jun-Hao Cheng,Chin-Fa Lee |发布日期:2012.7.20 摘要:Here The Iron-Catalyzed Cross-Coupling Reaction Of Alkyl Vinyl Halides With Thiols. While Many Works Are Devoted To The Coupling Of Thiols With Alkyl Vinyl Iodides, Interestingly, The Known S-Vinylation Of Vinyl Bromides And Chlorides Is Limited To 1-(2-Bromovinyl)Benzene And 1-(2-Chlorovinyl)Benzene. Investigation On The Coupling Reaction Of Challenging Alkyl Vinyl Bromides And Chlorides With Thiols