专利号:US-9795685-B2 优先权日:2012-08-21 标 题 :Haptens of aripiprazole 发明人:LIN RONGHUI; SALTER RHYS; DECORY THOMAS R; HRYHORENKO ERIC; REMMERIE BART M; SANKARAN BANUMATHI 权利人:JANSSEN PHARMACEUTICA NV 摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.
专利号:US-2010075297-A1 优先权日:2006-12-20 标题 :Photosensitive polypeptide and methods of their production and use 发明人:LAWRENCE DAVID S 权利人:LAWRENCE DAVID S 摘要:Methods for producing polypeptides caged with a photolabile group on one or more backbone nitrogens are provided, in which the photolabile group is added to a growing polypeptide chain during polypeptide synthesis. Photosensitive polypeptides produced by the methods are described, as are methods of using such photosensitive polypeptides to assay enzyme activity or inhibit protein-protein interactions. Methods for producing polypeptides caged with a photolabile group on one or more side chain nitrogens, where the photolabile group is incorporated into the side chain during polypeptide synthesis, are also provided.
专利号:US-8969535-B2 优先权日:2006-12-05 标 题:Photocleavable labeled nucleotides and nucleosides and methods for their use in DNA sequencing 发明人:WU WEIDONG; LITOSH VLADISLAV A; STUPI BRIAN P; METZKER MICHAEL L 权利人:WU WEIDONG; LITOSH VLADISLAV A; STUPI BRIAN P; METZKER MICHAEL L; LASERGEN INC 摘要:Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker to a photocleavable terminating group. The photocleavable-fluorescent group is designed to terminate DNA synthesis as well as be cleaved so that DNA oligomers can be sequenced efficiently in a parallel format. The design of such rapidly cleavable fluorescent groups on nucleotides and nucleosides can enhance the speed and accuracy of sequencing of large oligomers of DNA in parallel, to allow rapid whole genome sequencing, and the identification of polymorphisms and other valuable genetic information, as well as allowing further manipulation and analysis of nucleic acid molecules in their native state following cleavage of the fluorescent group.
专利号:US-2025101038-A1 优先权日:2021-12-24 标 题 :Compounds 发明人:BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG 权利人:Psylo Pty Ltd 摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
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