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📜苯乙酸乙酯置于indium(III) Bromide,1,1,3,3-四甲基二硅氧烷,碘体系中,用 氯仿 用作溶剂,化学反应 1.0H,以92%的收率获得2-碘代乙基苯
参考文献:铟(III)催化的羧酸的还原溴化和碘化反应,生成烷基溴化物和碘化物:范围,机理和一锅法转变为卤代烷和胺衍生物
标题:铟(III)催化的羧酸的还原溴化和碘化反应,生成烷基溴化物和碘化物:范围,机理和一锅法转变为卤代烷和胺衍生物
摘要:描述了高效的铟(III)催化的各种羧酸与1,1,3,3-四甲基二硅氧烷(tmds)和溴或碘源的还原溴化或碘化.该官能团互变对几种官能团具有高耐受性,例如卤素,羟基,硝基,烯烃部分和硫化物部分.该铟催化体系也适用于醛化,酰氯和酯的还原碘化.此外,该还原体系可通过添加亲核试剂用于一锅法合成卤代烷和胺衍生物.通过1 H和13 C NMR监测实验的时间过程以及相应的逐步反应,可以深入了解反应机理.
Doi:10.1021/jo401529J

专利信息

专利号:WO-2009115333-A1
优先权日:2008-03-20
标 题:Novel synthesis of praziquantel
发明人：DOEMLING ALEXANDER
权利人:DOEMLING ALEXANDER
摘要:The present invention discloses a novel and efficient synthesis of praziquantel (I).

专利号:WO-2017082924-A1
优先权日:2015-11-13
标题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE TERRENCE R JR; HYMEL DAVID
权利人:THE US SECRETARY DEPT OF HEALTH & HUMAN SERVICES
摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:US-2023357286-A1
优先权日:2020-07-24
标 题:Ketone synthesis and applications
发明人：KISHI YOSHITO; UMEHARA ATSUSHI
权利人:HARVARD COLLEGE
摘要:Provided are new nickel./zirconium-mediated coupling reactions useful in the synthesis of ketone-containing compounds, e.g., halichondrin natural products and related molecules. A feature of the present disclosure is the use of a nickel(I) catalyst in tandem with a nickel (II) catalyst in the Ni/Zr-mediated coupling reactions. Without wishing to be bound by any particular theory, the nickel (I) catalyst selectively activates the electrophilic coupling partner (i.e., the compound of Formula (A)), and the nickel(ll) catalyst selectively activates the nucleophilic coupling partner (i.e., a thioester of Formula (B)). This dual catalyst system leads to improved coupling efficiency and eliminates the need for a large excess of one of the coupling partners (i.e., a compound of Formula (A) or (B)).

专利号:US-4033949-A
优先权日:1976-04-14
标 题:Analogs of thromboxane B2 and processes for their synthesis
发明人：KELLY ROBERT C; NELSON NORMAN A
权利人:UPJOHN CO
摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 .sub.α). These analogs are particularly and especially useful as reproductive cycle control agents.

专利号:US-2008183007-A1
优先权日:2004-10-08
标 题 :Process For the Preparation of Alkyl Phosphinic Acids
发明人：THELIN MATS
权利人:ASTRAZENECA AB
摘要:The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative by a radical initiated reaction. The invention also relates to compounds obtainable by the method of the invention.

专利号:US-2015158020-A1
优先权日:2013-12-11
标题:Synthesis of zeolites using an organoammonium compound
发明人：NICHOLAS CHRISTOPHER P; MILLER MARK A
权利人:UOP LLC
摘要:A method for synthesizing a zeolite includes the steps of: (a) preparing an aqueous mixture comprising water, a substituted hydrocarbon and an amine; (b) reacting the aqueous mixture; (c) obtaining a solution comprising an organoammonium product; (d) forming a reaction mixture including reactive sources of M, Al, Si, optionally seeds of a layered material L, and the solution, wherein M is a metal; and (e) heating the reaction mixture to form the zeolite. The substituted hydrocarbon can be an α,ω-dihalogen substituted alkane, and the amine is preferably essentially incapable of undergoing pyramidal inversion.