CAS: 13613-65-5; Sodium (R)-3-Hydroxybutanoate

相似化合物

150-83-4 127604-16-4 1219804-68-8

上下游产品

CAS号110-15-6 琥珀酸； 丁二酸 | CAS号110-17-8 富马酸,反丁烯二酸 | CAS号513-85-9 2,3-丁二醇 | CAS号625-72-9 (R)-3-羟基丁酸

(R)-3-羟基丁酸甲酯置于sodium Hydroxide体系中,用 水 用作溶剂,化学反应 6.0H,以85%的收率获得(R)-(-)-3-羟基丁酸钠盐
参考文献:(R)-3-羟基丁酸及其盐的合成工艺
标题:(R)-3-羟基丁酸及其盐的合成工艺
摘要:本发明公开了一种制备(R)‑3‑羟基丁酸及其钠盐,钾盐,镁盐,钙盐的合成工艺,包括下述步骤:在有机溶剂中,加入摩尔比为1:0.0005~0.005的3‑氧代丁酸酯和钌络合物催化剂,于1巴~20巴氢气压力下,20oc~80oc反应12‑24小时,得到(R)‑3‑羟基丁酸酯;将(R)‑3‑羟基丁酸酯溶于水中,在低温下与氢氧化钠,氢氧化钾或者氢氧化钙反应2~12小时,得到(R)‑3‑羟基丁酸的钠盐,钾盐,或者钙盐;将(R)‑3‑羟基丁酸钠的水溶液通过732阳离子交换树脂处理,除去钠离子,得到(R)‑3‑羟基丁酸;将(R)‑3‑羟基丁酸与氢氧化镁反应,得到(R)‑3‑羟基丁酸镁.本发明制备的(R)‑3‑羟基丁酸及其钠,钾,钙,镁盐的ee值在90%以上,而且该方法环境污染小,成本低,后处理容易.

专利信息

专利号:US-6600029-B1
优先权日:1995-12-19
标题:Metabolic engineering of polyhydroxyalkanoate monomer synthases
发明人：SHERMAN DAVID H; WILLIAMS MARK D; XUE YONGQUAN
权利人:UNIV MINNESOTA
摘要:A novel pathway for the synthesis of polyhydroxyalkanoate is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalknoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalknoate synthase.

专利号:US-2003194784-A1
优先权日:2001-04-17
标题:DNA encoding methymycin and pikromycin
发明人：SHERMAN DAVID H; LIU HUNG-WEN; XUE YONGQUAN; ZHAO LISHAN
摘要:A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.

专利号:US-6265202-B1
优先权日:1998-06-26
标 题 :DNA encoding methymycin and pikromycin
发明人：SHERMAN DAVID H; LIU HUNG-WEN; XUE YONGQUAN; ZHAO LISHAN
权利人:UNIV MINNESOTA
摘要:A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.