CAS: 126-44-3; 2-Hydroxy-1,2,3-Propanetricarboxylate

📜在 Sodium Nitrate,1,4,7-三氮杂环壬烷-N,N',N''-三乙酸体系中,化学反应 0.03H,反应生成2-羟基丙烷-1,2,3-三羧酸根
参考文献:弱柠檬酸酯络合物形成ga(nota)的动力学
标题:弱柠檬酸酯络合物形成ga(nota)的动力学
摘要:由于68 Ga同位素在正电子发射断层扫描(pet)应用中的实际优势,镓络合物在生物医学成像中的重要性日益提高.68 Ga的半场时间很短(t 1/2 = 68分钟);因此必须在有限的时间内制备68 Ga配合物.用于pet成像的具有大环配体的镓配合物的形成反应的加速代表了显着的配位化学挑战.在这里,我们报告了由弱柠檬酸盐络合物(h 3 Nota = 1,4,7-三氮杂环壬烷-1,4,7-三乙酸)形成的高稳定性ga(nota)反应的详细动力学研究.已经使用以下方法对重金属化进行了研究71在较大的ph范围内(ph = 2.01-6.00)的ga NMR.Ga(nota)的形成是一个两步过程.首先,在快速平衡步骤中形成了含有配位柠檬酸盐gahnota(柠檬酸盐)*的单质子化中间体.该反应的决定速率的步骤是中间体的去质子化和缓慢的重排,伴随着柠檬酸盐的释放.观测到的反应速率显示出异常的ph依赖性,在ph
Doi:10.1021/ic201445E

专利信息

专利号:US-2024409495-A1
优先权日:2021-10-20
标 题 :Process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts
发明人：JAISANKAR PARASURAMAN; DEB INDUBHUSAN; BHATTACHARJEE PINAKI
权利人:COUNCIL SCIENT IND RES
摘要:Methods involving preparation of building blocks of 2,7-dihydroxy-9-fluorenone toward the synthesis of tilorone dihydrochloride salt and other salts (bromide, iodide, fluoride, citrate, oxalate, maleate, phosphate, tartrate, triflate, trifluoroacetate, tetrafluoroborate) of tilorone, and an efficient, safe, cost effective method for the preparation of 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 and its various salts are developed. The methods involve oxygenation of fluorene, nitration of fluorenone, followed by reduction and diazotization toward the formation of 2,7-dihydroxy-9-fluorenone, which is the key intermediate for the formation of 2,7-bis-[2-(diethylamino)ethoxy]-9-fluorenone-dihydrochloride (Tilorone dihydrochloride) and other tilorone salts. The synthesis method has relatively simple operation, mild reaction conditions, high yield, and simple process with yields of 80-97%. Subsequent product purification of this method uses filtration and crystallization methods, avoiding the existing methods of column chromatography. Therefore, the research of its synthetic method being with a wide range of applications from the drug development and material synthesis point of view.

专利号:US-9376461-B2
优先权日:2011-06-06
标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof
发明人：KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B
权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC
摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.

专利号:US-10662452-B2
优先权日:2016-09-05
标 题 :Strain of meyerozyma guilliermondii and its use in methods of catalytic synthesis of 2,5-dihydroxymethylfuran
发明人：LI NING; LI YANMEI; ZONG MINHUA
权利人:UNIV SOUTH CHINA TECH
摘要:A yeast strain and a method for the synthesis of 2,5-dihydroxymethylfuran using this strain are disclosed. The yeast strain is Meyerozyma guilliermondii SC 1103, which has been maintained in the China Center for Type Culture Collection (CCTCC, Wuhan, P.R. China) with an access No. of M2016144. The method for the synthesis of 2,5-dihydroxymethylfuran using this strain is described as follows: after pre-cultivation and cultivation, Meyerozyma guilliermondii SC 1103 cells are added into the buffer solutions containing 5-hydroxymethylfurfural and glucose; the biocatalytic reaction is conducted under designated conditions, thus affording 2,5-dihydroxymethylfuran. This disclosure has many advantages such as good selectivity, mild reaction conditions, environmental friendliness, high efficiency, and good yield.

专利号:US-2010087658-A1
优先权日:1996-08-06
标 题 :Methods and intermediates for synthesis of selective dpp-iv inhibitors
发明人：CAMPBELL DAVID ALAN; LEITAO EMILIA P T; WU ZHEN-PING; WANG PENG
权利人:PHENOMIX CORP
摘要:Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes.

专利号:US-2024239737-A1
优先权日:2023-01-13
标题 :Synthesis of Triisoamyl Citrate (Triisopentanol) and its Applications as a Solvent, Plastizer and Component of Cosmetic and Aerosol Formulations
发明人：SATO SETSUO
权利人:BRASIL BIO FUELS S A
摘要:The present invention is based on the synthesis of triisoamyl citrate (triisopentanol citrate) and its applications as a plasticizer for polyvinyl chloride polymers, natural and synthetic rubbers, industrial solvents, replacing petrochemical-based products such as Phthalates (Dioctyl Phthalate, Diisononyl Phthalate, Dibutyl Phthalate), Acetylated tributylcitrate, epoxidized fatty esters, isoparaffins. It is a 100% renewable, high-performance, non-toxic, biodegradable product with an extremely competitive cost. With the increase in corn alcohol production in Brazil, this technology and product adds value to the fusel oil co-product generated in corn alcohol plants.

专利号:US-4029768-A
优先权日:1971-03-16
标 题 :Composition for application to the animal brain for synthesis of brain components involved in the learning process, and method
发明人：PENN NATHAR W
权利人:PENN NATHAR W
摘要:A composition for application to the animal brain (this term is used to include both humans and lower animals) for synthesis of brain components involved in the learning process, thereby facilitating learning. The composition comprising brain deoxyribonucleic acid containing 5-hydroxymethyloytosine ranging from about 8 to 15% of the total cytosines present. The invention includes dosage and method of preparation.