CAS: 120740-10-5; (6-Bromopyridin-3-yl)Methanamine

相似化合物

1251953-04-4 864266-29-5 889676-37-3

上下游产品

14H9BrN2O2C14H9BrN2O2 2-Bromo-5-methylpyridine 2-bromo-5-bromomethylpyridine 2-bromo-5-cyanopyridine1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (6-bromo-pyridin-3-ylmethyl)-amide 2-(4-amin°Cyclohexyl)-N6-(6-bromo-pyridin-3-ylmethyl)-9-cyclopentyl-9H-purine-2,6-diamineN2-(4-amin°Cyclohexyl)-N6-(6-bromo-pyridin-3-ylmethyl)-9-cyclopentyl-9H-purine-2,6-diamine 2-(4-amin°Cyclohexyl)-9-cyclopentyl-N6-(6-furan-2-yl-pyridin-3-ylmethyl)-9H-purine-2,6-diamineN2-(4-amin°Cyclohexyl)-9-cyclopentyl-N6-(6-furan-2-yl-pyridin-3-ylmethyl)-9H-purine-2,6-diamine 2-(4-amin°Cyclohexyl)-9-cyclopentyl-N6-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamineN2-(4-amin°Cyclohexyl)-9-cyclopentyl-N6-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine

📜2-溴-5-甲基吡啶置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈,乌洛托品体系中,用 氯仿,1,2-二氯乙烷 用作溶剂,化学反应 16.25H,反应生成5-氨甲基-2-溴吡啶
参考文献:A Novel Series Of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors
标题:A Novel Series Of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors
摘要:The Inhibition Of Overactive Cdks During Cancer Remains An Important Strategy In Cancer Drug Development. We Synthesized And Screened A Novel Series Of 2-Substituted-6-Biarylmethylamino-9-Cyclopentylpurine Derivatives For Improved Cdk Inhibitory Activity And Antiproliferative Effects. One Of The Most Potent Compounds,6B,Exhibited Strong Cytotoxicity In The Human Melanoma Cell Line G361 That Correlated With Robust Cdk1 And Cdk2 Inhibition And Caspase Activation. In Silico Modeling Of 6B In The Active Site Of Cdk2 Revealed A High Interaction Energy,Which We Believe Is Due To The 6-Heterobiarylmethylamino Substitution Of The Purine Moiety.
Doi:10.1021/jm4006884

专利信息

专利号:CN-103626693-A
优先权日:2012-08-28
标 题 :A class of pleuromutilin derivatives, its pharmaceutical composition and its synthesis method and application