CAS: 120595-80-4; Sodium (2S,3S,4S,5R,6S)-6-(4-Acetamidophenoxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylate
该化合物是一种合成甘基二烯酸共聚物,广泛用作酶实验的基质,特别是用于β-甘基丙烯菊酯活动研究,其主要优点包括高纯度和稳定性,确保生物化学和临床研究的可靠和可复制结果;化合物的水溶性和明确界定的裂变特性使其适合光谱度测定或氟度检测方法;它是药物代谢研究中的一个关键工具,有助于对葡萄化途径和酶动能学进行研究;钠盐形式增强了水温缓冲中的溶性,便利其在体外诊断应用中的使用;其一贯性能支持对复杂生物基质中的酶活动进行准确的量化.
- 英文名称Sodium (2S,3S,4S,5R,6S)-6-(4-Acetamidophenoxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylate
- 中文名称P-乙酰氨基苯-B-D-葡萄糖酸钠盐
- IUPAC名称sodium (2S,3S,4S,5R,6S)-6-(4-acetamidophenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
- 其它别名P-Acetamidophenyl-B-D-Glucuronide Sodium Salt; P-Acetamidophenyl Beta-D-Glucuronide Sodium Salt; Paracetamol Glucuronide; Paracetamol Glucuronide Sodium Salt; Sodium 6-(4-Acetamidophenoxy)-3,4,5-Trihydroxy-2-Oxanecarboxylate; Paracetamol Impurity 2; 4-Acetamidophenyl Beta-D-Glucuronide, Sodium Salt; Acetaminophen Glucuronide
- CAS编号120595-80-4
- MFCD编号:MFCD00153898
- FDA UNII编号:2P8DNC7A3V
- 分子式:C14H16NNaO8分子量:349.27
- 产品CID: 274854
- 同类组份化合物CAS16110-10-4 (free acid)120595-80-4 (sodium)
- 产品分类生物化工 → 糖类化合物 → 单糖
物理性质
MSDS等安全信息
上下游产品
CAS号30824-21-6 4-乙酰氨基苯基-2,3,4-... | CAS号72692-06-9 2,3,4-三-O-乙酰基-α... | CAS号92420-89-8 2,3,4-三-O-乙酰基-Β...合成工艺路线路线简述
- 合成目标产物 Acetaminophen Glucuronide Sodium Salt 主要起始原料 4-Acetamidoophenyl Triacetyl-Beta-D-Glucopyranosiduronic Acid, Methyl Ester
- (文献来源)合成步骤主要原料 4-Acetamidoophenyl Triacetyl-Beta-D-Glucopyranosiduronic Acid, Methyl Ester
📜3,4,6-三邻乙酰基-Alpha-D-吡喃葡萄糖 1,2-(原酸甲酯)置于水体系中,用 四氢呋喃,甲醇,二氯甲烷 用作溶剂,化学反应 5.5H,反应生成P-乙酰氨基苯-B-D-葡萄糖酸钠盐
参考文献:Preparation And Characterisation Of Solid State Forms Of Paracetamol-O-Glucuronide
标题:Preparation And Characterisation Of Solid State Forms Of Paracetamol-O-Glucuronide
摘要:The Synthesis And Crystallisation Of The Pharmaceutically Important Metabolite,Paracetamol-O-Glucuronide,Is Described. Hydrated And Anhydrous Forms Of The Target Molecule Have Been Characterised By Pxrd,Dsc And Tga. In Addition,A Methanol Solvate Has Been Analysed,Including Single Crystal Analysis,Which Represents The First Structure Solution For This System. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Carres.2011.12.018
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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主要参考文献
1: Ji Y, Azuine RE, Zhang Y, Hou W, Hong X, Wang G, Riley A, Pearson C, Zuckerman B, Wang X. Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood. JAMA Psychiatry. 2020 Feb 1;77(2):180-189. doi: 10.1001/jamapsychiatry.2019.3259.
2: Noda T, Kato R, Ozato Y, Kawai Y, Yamamoto M, Kagawa Y, Azuma M, Yamamoto K, Kusanagi M, Uryu K, Harada H, Ijiri Y, Hayashi T, Tanaka K. Decreased plasma acetaminophen glucuronide/acetaminophen concentration ratio warns the onset of acetaminophen-induced liver injury. Biopharm Drug Dispos. 2022 Jun;43(3):108-116. doi: 10.1002/bdd.2316. Epub 2022 May 17. 70(2):315-9. doi: 10.1002/mrm.24485. Epub 2012 Sep 28.
4: Jones J, Kahl S, Carvalho F, Barosa C, Roden M. Simplified analysis of acetaminophen glucuronide for quantifying gluconeogenesis and glycogenolysis using deuterated water. Anal Biochem. 2015 Jun 15;479:37-9. doi: 10.1016/j.ab.2015.03.018. Epub 2015 Mar 20. 295(1):44-50. 32(11):e4331. doi: 10.1002/bmc.4331. Epub 2018 Sep 6. 44(6):797-804. doi: 10.1097/FTD.0000000000000993. 40(34):2883-2896. doi: 10.1093/eurheartj/ehz235.
合成参考文献
参考DOI号:10.1016/j.carres.2011.12.018
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