CAS: 1188227-29-3; 7-Bromo-2-Chlorobenzo[d]Thiazole
该化合物是一种卤代苯甲醚衍生物,在有机合成和制药中间体中有很大用途.它独特的溴和氯替代物增强了反应性,使其成为相互交织反应的多功能建筑块,如铃木或Buchwald-Hartwig的结合.该化合物的电子提取特性促进了苯并氮核核心的功能化,使得复杂的循环结构得以合成.它因其在开发农用化学,染料和生物活性分子方面的作用而特别受到重视.在标准条件下,高纯度和稳定性确保了研究和工业应用的一贯性能.由于它的卤化性质,建议进行适当的处理和储存.
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📜3-溴-2-氟苯胺置于磺酰氯体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 4.0H,反应生成7-溴-2-氯苯并噻唑
参考文献:Small Molecules Enhance Functional O-Mannosylation Of Alpha-Dystroglycan
标题:Small Molecules Enhance Functional O-Mannosylation Of Alpha-Dystroglycan
摘要:Alpha-Dystroglycan (Alpha-Dg),A Highly Glycosylated Receptor For Extracellular Matrix Proteins,Plays A Critical Role In Many Biological Processes. Hypoglycosylation Of Alpha-Dg Results In Various Types Of Muscular Dystrophies And Is Also Highly Associated With Progression Of Majority Of Cancers. Currently,There Are No Effective Treatments For Those Devastating Diseases. Enhancing Functional O-Mannosyl Glycans (Fog) Of Alpha-Dg On The Cell Surfaces Is A Potential Approach To Address This Unmet Challenge. Based On The Hypothesis That The Cells Can Up-Regulate Fog Of Alpha-Dg In Response To Certain Chemical Stimuli,We Developed A Cell-Based High-Throughput Screening (Hts) Platform For Searching Chemical Enhancers Of Fog Of Alpha-Dg From A Large Chemical Library With 364,168 Compounds. Sequential Validation Of The Hits From A Primary Screening Campaign And Chemical Works Led To Identification Of A Cluster Of Compounds That Positively Modulate Fog Of Alpha-Dg On Various Cell Surfaces Including Patient-Derived Myoblasts. These Compounds Enhance Fog Of Alpha-Dg By Almost Ten Folds,Which Provide Us Powerful Tools For O-Mannosylation Studies And Potential Starting Points For The Development Of Drug To Treat Dystroglycanopathy. (C) 2015 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2015.11.011
专利信息
专利号:US-8378104-B2
优先权日:2010-02-11
标 题 :7-aminofuropyridine derivatives
发明人：HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
权利人:OSI PHARMACEUTICALS LLC; HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.
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合成参考文献
参考DOI号:10.1016/j.bmc.2015.11.011
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