CAS: 115-22-0; 3-Hydroxy-3-Methyl-2-Butanone

相似化合物

5396-58-7 7431-25-6 24347-59-9

上下游产品

CAS号35298-48-7 2,5-二甲基-3(2H)呋喃酮 | CAS号20099-40-5 1-(1,3-benzodio... | CAS号189102-39-4 3-[tert-butyl(d... | CAS号594-61-6 2-羟基异丁酸 | CAS号76-09-5 频哪醇 | CAS号29456-04-0 prop-1-en-2-ol | CAS号75-07-0 乙醛 | CAS号431-03-8 2,3-丁二酮 | CAS号67-63-0 异丙醇 | CAS号67-64-1 丙酮

3-甲基-2-丁酮置于氧气,Caesium Carbonate,亚磷酸三乙酯体系中,用 二甲基亚砜 用作溶剂,25.0 °C,101.33 Kpa 条件下,反应 24.0H,以80%的收率获得3-羟基-3-甲基-2-丁酮
参考文献:高效c 轻度条件下氧对羰基化合物的h羟化反应
标题:高效c 轻度条件下氧对羰基化合物的h羟化反应
摘要:描述了无过渡金属的cs 2 Co 3催化的羰基化合物的α-羟基化,其中o 2为氧源.该反应为叔α-羟基羰基化合物提供了一种有效的方法,这些叔α-羟基羰基化合物是极有价值的化学物质,广泛用于化学和制药行业.简单的条件和使用分子氧作为氧化剂和氧源使该协议非常环保和实用.此转换是高效的,并且对叔c(sp 3)h键裂解具有高度选择性.
Doi:10.1002/anie.201308698

专利信息

专利号:US-4062865-A
优先权日:1974-04-05
标 题:Process for the synthesis of substituted indolenines
发明人：MOGGI PIETRO ANTONIO
权利人:SNAM PROGETTI
摘要:A process for the preparation of substituted indolenines of the formula: ##STR1## wherein R is hydrogen, alkyl, aryl or cycloalkyl, halogen, or a functional group selected from among cyano, hydroxyl, alkoxy, nitro or sulphonic groups, and wherein R 1 , R 2 and R 3 are the same, or different, and are selected from alkyl, aryl or cycloalkyl radicals, comprising reacting in the presence of an organic solvent an aromatic amine of the formula: ##STR2## with a tertiary hydroxyketone of the formula: ##STR3## wherein R, R 1 , R 2 and R 3 have the same meanings as defined above, in the presence of a catalyst selected from mineral acids, organic acids, Lewis acids or ionic exchange resins in acid form, and wherein said aromatic amine is slightly in excess, to form first an imine of the formula: ##STR4## under reaction conditions wherein the solvent is removed by azeotropic distillation, and thereafter continuing the reaction to remove water and cyclizing to the desired indolenines. In a preferred embodiment, 2,3,3-trimethylindolenine is prepared by reacting an excess of aniline with 3-methyl-3-hydroxybutan-2-one in the presence of ZnCl 2 as catalyst utilizing benzene as solvent. The substituted indolenines obtained are useful in production of dyes and other compounds useful in the dyeing and photographic industries.

专利号:US-8143437-B2
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

专利号:WO-03080621-A1
优先权日:2002-03-19
标题:Process and intermediates to substituted imidazopyrimidines
发明人：LI WENJIE; CAI DONGWEI; HOERRNER R SCOTT; JENSEN MARK S; LARSEN ROBERT D; PETASIS NICOS A
权利人:MERCK & CO INC; LI WENJIE; CAI DONGWEI; HOERRNER R SCOTT; JENSEN MARK S; LARSEN ROBERT D; PETASIS NICOS A
摘要:A novel process is provided for the preparation of imidazo[1,2-α]pyrimidines which are substituted at the 3-position with a substituted chlorophenyl group. Such compounds are useful in the synthesis of GABAA receptor ligands for the treatment of deleterious mental disorders. Also provided are intermediates obtained from the process useful in the synthesis of GABAA receptor ligands.

专利号:US-10017435-B2
优先权日:2014-06-10
标 题 :Process for the preparation of a phenylindan compound
发明人：NORCINI GABRIELE; CASIRAGHI ANGELO; MENEGUZZO ENZO; FLORIDI GIOVANNI; LI BASSI GIUSEPPE
权利人:IGM RESINS ITALIA SRL; IGH RESINS ITALIA S R L
摘要:The present invention refers to a process for producing 5-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl]-3-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl-phenyl]-2,3-dihydro-1,1,3-trimethyl-1H-indene (dimer isomer 5) that comprises the synthesis from cumene and dimerization of 2-methyl-1-(4-(prop-1-en-2-yl)phenyl)propan-1-one in the presence of acid catalysts.

专利号:US-2005239725-A1
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof

专利号:US-6232467-B1
优先权日:1996-06-28
标 题:Method for the synthesis of amines and amino acids with organoboron derivatives
发明人：PETASIS NICOS A; ZAVIALOV ILIA A
权利人:UNIV SOUTHERN CALIFORNIA
摘要:Amines and amino acids are prepared by reacting an amine, a carbonyl derivative, and an organoboron compound under mild conditions.