CAS: 101555-61-7; Boc-D-Beta-Homophenylalanine

相似化合物

138165-77-2 193954-28-8 120378-17-8

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号131270-08-1 (R)-3-氨基-4-苯基丁酸 | CAS号115313-19-4 (s)-3-b°C-amino... | CAS号186581-53-3 重氮甲烷 | CAS号18942-49-9 N-B°C-D-苯丙氨酸 | CAS号106454-69-7 N-B°C-D-苯丙氨醇

N-Boc-D-苯丙氨醇置于氢氧化钾体系中,用 吡啶,甲醇,二甲基亚砜 用作溶剂,化学反应 37.0H,反应生成(R)-3-叔丁氧羰基氨基-4-苯基丁酸
参考文献:Syntheses And Biological Activities Of Bombesin Analogs Modified In The C-Terminal Dipeptide Part
标题:Syntheses And Biological Activities Of Bombesin Analogs Modified In The C-Terminal Dipeptide Part
摘要:Bombesin Receptor Antagonists Are Possible Therapeutic Agents Due To Their Ability To Act As Inhibitors Of Cellular Proliferation. On The Basis Of Our Hypothesis On The Mechanism Of Action Of Gastrin Associating An Activating Enzyme System To The Receptor And On The Results Reported In The Litterature,We Have Synthesized Bombesin Analogues Which Have Been Modified In The C-Terminal Leu(13)-Leu(14) Amide Part. We Have Shown That Modification In The C-Terminal Part Of The Bombesin Strongly Affected The Biological Activity In Rat Pancreatic Acini. The Most Potent Compound Which Is Described Here,H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-Psi(Ch2)Leu-Nh2,Was Able To Recognize The Bombesin Receptor On Rat Pancreatic Acini (Ki 4.3 Nm) And Antagonized The Bombesin Stimulated Amylase Secretion (Ki 7.7 Nm).
Doi:10.1016/s0223-5234(99)80063-4

专利信息

专利号:US-2003158436-A1
优先权日:1999-03-10
标题:Synthesis of alpha--amino-alpha, alpha'- dihaloketones and process for the preparation of beta--amino acid derivatives by the use of the same

专利号:US-6573399-B1
优先权日:1999-03-10
标题:Synthesis of α-amino-α′, α′-dihaloketones and process for the preparation of β-amino acid derivatives by the use of the same
发明人：NISHIYAMA AKIRA; INOUE KENJI
权利人:KANEKA CORP
摘要:The present invention provides a commercially profitable process for producing a β-amino acid ester derivative n which comprises reacting an α-amino acid ester derivative with a base and a dihalomethane, n reacting the same with a lithium amide and an alkyllithium in succession, n and treating the reaction product with an acid in an alcohol.

专利号:EP-1078919-A1
优先权日:1999-03-10
标题 :SYNTHESIS OF $g(a)-AMINO-$g(a)',$g(a)'-DIHALOKETONES AND PROCESS FOR THE PREPARATION OF $g(b)-AMINO ACID DERIVATIVES BY THE USE OF THE SAME

专利号:EP-1078919-B1
优先权日:1999-03-10
标题 :Synthesis of alpha-amino-alpha',alpha'-dihaloketones and process for the preparation of beta)-amino acid derivatives by the use of the same