四甲基硅烷置于三氧化硫体系中,化学反应生成三甲基硅基甲烷磺酸酯 参考文献:So 3-锗,锗和锌的金属金属有机硅 标题:So 3-锗,锗和锌的金属金属有机硅 摘要:由于其强大的亲电特性,三氧化硫可以插入碳与硅,锗,锡和铅元素之间的键中.该反应在非常温和的条件下进行,通常得到磺酸的有机金属衍生物,R 3 M =oso 2 R(m = Si,Ge,Sn和pb; R =烷基或芳基).在合适的条件下,可以检测到有机金属硫酸盐和磺酸酐(r 3 Mo)2 So 2和rso 2 Oso 2 R作为副反应的产物.描述了所得产物的性质并讨论了反应机理. Doi:10.1016/s0022-328X(00)86326-3
专利信息
专利号:WO-2024103123-A1 优先权日:2022-11-17 标题 :The synthesis of omapatrilat 发明人:VITALE ROMINA; MARTIN VINCENT ALEXANDRE; FABER WIJNAND; SOMMER ROMAN 权利人:ENDOTHELIUM SCANNING NANOTECHNOLOGY LTD 摘要:Described herein are improved methods of making Compound 1 (4S,7S,10aS)-4-((S)-2- mercapto-3-phenylpropanamido)-5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, or Omapatrilat, and purified Omapatrilat obtained from the improved methods.
专利号:US-2023099421-A1 优先权日:2019-12-17 标题 :A new method of 18f labelling and intermediate salts 发明人:YOUNG ROWAN DRURY; MANDAL DIPENDU; GUPTA RICHA; JAISWAL AMIT KUMAR 权利人:NAT UNIV SINGAPORE 摘要:Disclosed herein is a salt of formula I: where R 1 , X, n, R, R 1 , Y, m, p, q, Z and o are as defined herein. Also disclosed herein are methods of using said salts in chemical synthesis, such as to prepare compounds isotopically enriched in 18F for use in PET & imaging, as well as methods to make the compounds of formula I.
专利号:WO-2025078040-A1 优先权日:2023-10-09 标 题 :Lysine salt and method of manufacturing a lysine derivative 发明人:HINTERMANN TOBIAS; SCHWINDLING JOACHIM; RÜEFLI PASCAL; SCHÖNLEBER RALPH O; WILLIG FELIX; MELZIG LAURIN; ERMERT PHILIPP; KÜMIN MICHAEL; SCHWIZER NATASCHA; SCHNEIDER ANGELIKA; SCHMID LUCIUS 权利人:BACHEM HOLDING AG 摘要:The invention relates to a Bsmoc-protected lysine salt of formula (1 X ), e.g., a hydrochloric acid salt (n = 1, HY = hydrochloric acid). It further relates to a method of manufacturing Bsmoc-protected lysine derivatives, which employs the Bsmoc-protected lysine salt of formula (1 X ) and comprises the step of reacting the epsilon amino group of lysine with an 10 activated carboxylic acid derivative. Some of the obtainable Bsmoc-protected lysine derivatives with their side chain modification are useful as starting materials in solid phase peptide synthesis.
专利号:EP-4619408-A1 优先权日:2022-11-17 标题 :The synthesis of omapatrilat
参考标题:Synthesis And Mass Spectra Of 4-O-Acetyl-1,5-Anhydro-2,3,6-Tri-O-Ethyl-D-Glucitol And The Positional Isomers Of 4-O-Acetyl-1,5-Anhydro-Di-O-Ethyl-O-Methyl-D-Glucitol And 4-O-Acetyl-1,5-Anhydro-O-Ethyl-Di-O-Methyl-D-Glucitol 作者:Samuel G. Zeller,Anello J. D'Ambra,Michael J. Rice,Gary R. Gray |发布日期:1988.10 摘要:6-Tri-O-Ethyl-D-Glucitol. Described Herein Is The Independent Synthesis Of These Derivatives, Except For The First (Which Had Been Reported); And Their 1H-N.M.R. Spectra, Chemical-Ionization (Nh3) Mass Spectra, And Electron-Impact Mass Spectra Are Tabulated.
合成参考文献
摘要:Spitzner, D., Science of Synthesis, (2005) 15, 60. 摘要:Drabowicz, J.; Kiełbasiński, P.; Łyżwa, P.; Zając, A.; Mikołajczyk, M., Science of Synthesis, (2008) 39, 60.