CAS: 100367-36-0; 3-Amino-2-Bromophenol

相似化合物

101935-40-4 100367-37-1 55120-56-4

上下游产品

2-bromo-3-hydroxy-1-nitrobenzene Hexanoic acid 2-bromo-3-(2,2-dimethyl-propionylamino)-phenyl ester N-(3-methoxyphenyl)pivalamide N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide2-bromo-3-hydroxy-N-tosylaniline (S)-4-[(E)-3-(3-Amino-2-bromo-phenoxy)-propenyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (S)-4-[(Z)-3-(3-Amino-2-bromo-phenoxy)-propenyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 2-bromo-3-iodophenol

📜N-(3-甲氧基苯基)-2,2-二甲基丙酰胺置于盐酸,正丁基锂,三氯化铝,溴体系中,化学反应 18.5H,反应生成3-氨基-2-溴苯酚
参考文献:Effect Of Alteration Of The Heterocyclic Nucleus Of Indolactam V On Its Isoform Selectivity For Pkc. Palladium-Catalyzed Route To Benzofuran Analogs Of Ilv
标题:Effect Of Alteration Of The Heterocyclic Nucleus Of Indolactam V On Its Isoform Selectivity For Pkc. Palladium-Catalyzed Route To Benzofuran Analogs Of Ilv
摘要:The Discovery Of Isoform-Selective Modulators Of Protein Kinase C (Pkc) Appears Worthwhile In Further Defining The Roles Of The Individual Pkc Isoforms In Cell Type-Specific Processes. In Comparison With The Phorbol Esters,Little Information Is Available Regarding The Isoform Selectivity Of The Teleocidin Family. Blumberg Has Reported Recently That 7-N-octylindolactam V Exhibits Little If Any Selectivity For The Isoforms Tested. In Order To Probe The Possibility Of Developing Isotype-Selective Agents Based On The Indolactam V (Ilv) Structure,We Sought To Explore Replacement Of The Indole Nucleus By A Benzofuran Ring. Herein We Describe A Novel Palladium-Catalyzed Route To Four Benzofuran Analogues 11A-D Of Ilv Together With Details Of Their Isoform Selectivity. Of Considerable Interest Is The Unexpected Finding That This Subtle N To O Structural Change Leads To A Compound (11B) That Is Modestly More Like 12,13-Dibutyrate Phorbol And Less Like N-octyl-Ilv In Its Pattern Of Activity. Moreover,The Effect Of Introducing An Additional Stereocenter At C-14 Into These Benzofurans Was Explored,And A Clear Preference For R-Stereochemistry At The C-14 Center Of The Teleocidin Family Was Found,Thus Providing Additional Verification Of Previously Published Structural Correlations Between The Families Of Pkc Activators. Overall,The Present Findings Provide An Important New Direction In The Quest For Isoform-Selective Activators Of Pkc.
Doi:10.1021/ja00130A003

专利信息

专利号:KR-20220169970-A
优先权日:2021-06-21
标题 :Method for synthesis of aminobenzyne and multisubstituted organic nitrogen compounds using aza-brook rearrangement and multisubstituted organic nitrogen compounds prepared using the same