CAS: 84249-14-9; 2-Amino-4-Bromopyridine

相似化合物

207799-10-8 909712-10-3 329974-09-6

上下游产品

2,4-dibromopyridine 2-methyl-4-nitropyridine N-oxide N-(6-bromo-3-pyridinyl)-N'-(3-methylphenyl)urea 4-(pyridin-3-yl)pyridin-2-amine 4-(2-Amino-pyridin-4-yl)-2-(2-amino-pyrimidin-4-yl)-phenol

4-溴吡啶盐酸盐置于ammonium Hydroxide,硫酸,溴,Iron(II) Sulfate,Sodium Hydroxide体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 3.0H,反应生成 2-氨基-4-溴吡啶
参考文献:2-氨基-4-溴吡啶的合成方法
标题:2-氨基-4-溴吡啶的合成方法
摘要:本发明涉及药物中间体合成领域,具体涉及2‑氨基‑4‑溴吡啶的合成方法.本发明提供一种2‑氨基‑4溴吡啶的制备方法,包括以下步骤:(1)酯化反应:4‑溴吡啶盐酸盐酯化得到4‑溴吡啶‑2‑甲酸乙酯粗品;(2)氨化反应:4‑溴吡啶‑2‑甲酸乙酯粗品经氨化得到4‑溴吡啶‑2‑甲酰胺;(3)霍夫曼降解反应:4‑溴吡啶‑2‑甲酰胺经霍夫曼降解得到2‑氨基‑4‑溴吡啶;其合成路线如式i所示.本发明所提供的方法原料成本低廉,收率高,反应操作简单,三废处理方便,易于实现工业化.

专利信息

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-6017926-A
优先权日:1997-12-17
标题 :Integrin receptor antagonists
发明人：ASKEW BEN C; COLEMAN PAUL J; DUGGAN MARK E; HALCZENKO WASYL; HUTCHINSON JOHN H; MEISSNER ROBERT S; PATANE MICHAEL A; WANG JIABING
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.

专利号:EP-3083583-A1
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof

专利号:CN-113235116-B
优先权日:2021-05-12
标题 :A kind of electrochemical synthesis method of bromopyridine derivatives

专利号:WO-2014008197-A1
优先权日:2012-07-03
标 题:Heterocyclic modulators of lipid synthesis

专利号:EP-1040111-B1
优先权日:1997-12-17
标 题:Integrin receptor antagonists
发明人：DUGGAN MARK E; MEISSNER ROBERT S; HUTCHINSON JOHN H; HALCZENKO WASYL; ASKEW BEN C; COLEMAN PAUL J; PATANE MICHAEL A; WANG JIABING; PERKINS JAMES J
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.