CAS: 65996-02-3; 2-Bromo-4-Methylnicotinonitrile

该化合物是一种多用途的七环环化合物,广泛用作制药和农用化学合成的关键中间体,其溴和西亚诺功能组使其成为交叉反应,核生殖器替代和其他变异的宝贵构件.甲基代用品在有针对性的修改中增强了其反应性和选择性.该化合物因其稳定的,但可变的结构,在开发活性药物成分和特殊化学品方面特别有用.具有高纯度,以确保研究和工业应用的一贯性能.建议,在受控条件下进行适当处理,因为其具有再活动性.

结构式图片

相似化合物

1003711-35-0 1260024-26-7 1289265-76-4

物理性质

MSDS等安全信息

合成工艺路线路线简述

  • 合成目标产物 2-Bromo-4-Methylpyridine-3-Carbonitrile 主要起始原料 Propanedinitrile, 2-[3-(Dimethylamino)-1-Methyl-2-Propen-1-Ylidene]-
  • (文献来源)合成步骤主要原料 Propanedinitrile, 2-[3-(Dimethylamino)-1-Methyl-2-Propen-1-Ylidene]-
📜2-甲氧基-4-甲基吡啶-3-甲腈置于磷酸,吡啶溴化氢盐,三溴氧磷体系中,用 苯 作为反应溶剂,化学反应 96.0H,以50%的收率获得产物2-溴-4-甲基吡啶-3-甲腈
参考文献:Victory,P.; Borrell,J. I.; Castejon,P.,Anales De Quimica,1993,Vol. 89,P. 625-628
标题:Victory,P.; Borrell,J. I.; Castejon,P.,Anales De Quimica,1993,Vol. 89,P. 625-628

海关参考信息

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Investigating The Continuous Synthesis Of A Nicotinonitrile Precursor To Nevirapine
作者:Ashley R Longstreet,Suzanne M Opalka,Brian S Campbell,B Frank Gupton,D Tyler Mcquade
摘要:2-Chloro-3-Amino-4-Picoline (Capic) Is A Strategic Building Block For The Preparation Of Nevirapine, A Widely-Prescribed Non-Nucleosidic Reverse Transcriptase Inhibitor For The Treatment Of Hiv-Infected Patients. A Continuous Synthesis To The Bromo Derivative Of A Capic Intermediate, 2-Bromo-4-Methylnicotinonitrile, That Terminates In A Dead-End Crystallization Is Described. The Route Uses Inexpensive, Acyclic Commodity-Based Raw Materials And Has The Potential To Enable Lower Cost Production Of Nevirapine As Well As Other Value Added Structures That Contain Complex Pyridines. The Route Terminates In A Batch Crystallization Yielding High Purity Capic. This Outcome Is Expected To Facilitate Regulatory Implementation Of The Overall Process.

合成参考文献


摘要:Ley, S. V.; Browne, D. L.; OʼBrien, M., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 292.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知