CAS: 630-25-1; 1,2-Dibromotetrachloroethane

上下游产品

CAS号127-18-4 四氯乙烯 | CAS号76-01-7 五氯乙烷 | CAS号594-18-3 二溴二氯甲烷 | CAS号7726-95-6 溴素 | CAS号1009334-28-4 4,5-二溴烟酸 | CAS号127-18-4 四氯乙烯 | CAS号2648-53-5 1-bromo-1,2,2-t... | CAS号1273-73-0 溴代二茂铁 | CAS号36667-05-7 2,3,4-tribromob... | CAS号76-12-0 1,2-二氟四氯乙烷 | CAS号7778-01-0 3,5-二氯苄基溴 | CAS号69410-45-3 1-benzyl-3-(bro...

四氯乙烯置于溴体系中,化学反应 2.0H,以94%的收率获得产物1,2-二溴四氯乙烷
参考文献:1,2-二溴四氯乙烷:一种有效的试剂,可通过修饰的appel反应进行许多转化
标题:1,2-二溴四氯乙烷:一种有效的试剂,可通过修饰的appel反应进行许多转化
摘要:已开发出一种高效且简便的方法,可在温和的条件下使用三苯基膦(pph $ _ {3})$ / 1,2-二溴四氯乙烷(dbtce)络合物在多种条件下从多种醇中合成烷基溴化物,且收率极高,且时间短(5分钟).该方法也可以用于以非常高的对映体过量将手性醇转化为其相应的溴化物.pph $ _ {3} $ / Dbtce配合物也已成功应用于温和条件下环状醚的开环反应.通过在这项工作中对appel反应方案进行修改,还可以在非常温和的实验条件下成功完成酯化,酰胺化和酸酐的形成.
DOI:10.3906/kim-1804-41

专利信息

专利号:US-12240835-B2
优先权日:2018-09-18
标题:Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity
发明人：ROMERO F ANTHONY; KIRSCHBERG THORSTEN A; HALCOMB RANDALL; XU YINGZI
权利人:TERNS PHARMACEUTICALS INC
摘要:Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

专利号:US-11512062-B2
优先权日:2018-10-15
标 题:Process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them
发明人：BEAUREGARD LOUIS-PHILIPPE; BERTRAND MARTIAL; GIGUERE PASCALL; HARDOUIN CHRISTOPHE; SCHIAVI BRUNO
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I):

专利号:US-2024010638-A1
优先权日:2020-11-13
标题:Improved synthesis of crac channel inhibitors
发明人：STAUDERMAN KENNETH; DUNN MICHAEL; OLMSTEAD KAY
权利人:CALCIMEDICA INC
摘要:Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

专利号:US-12435034-B2
优先权日:2020-10-19
标 题 :Process of preparing 3-fluoro-5(((1R,2AR)-3,3,4,4-tetrafluoro-1,2A-dihydroxy-2,2A,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)-oxy)benzonitrile
发明人：FU JIPING; LOU YAN; HE YIGANG; SHI YUETAO; ZHOU PENG; LI XINGXING
权利人:NIKANG THERAPEUTICS INC
摘要:Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.

专利号:US-11344858-B2
优先权日:2019-05-02
标 题 :Micro-electrolysis reactor for ultra fast, oxidant free, C—C coupling reaction and synthesis of daclatasvir analogs thereof
发明人：SINGH AJAY KUMAR; PABBARAJA SRIHARI; GHOSH SUBHASH; BHUSHAN MAHAJAN; MUJAWAR TAUFIQUEAHMED
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, C—C coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.

专利号:WO-2020078875-A1
优先权日:2018-10-15
标题:New process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them