CAS: 589-66-2; Isobutyl But-2-Enoate

相似化合物

638-10-8 24410-84-2 7283-69-4

专利信息

专利号:US-6140510-A
优先权日:1993-05-06
标 题 :Optically active 3-(1-(carbamoyl))alkyl-2-oxo-pyrrolidines and optically active 3-(1-(alkylamido))alkyl-2-oxo-pyrrolidines
发明人：MCWHORTER WILLIAM W; FLECK THOMAS J; PEARLMAN BRUCE A
权利人:UPJOHN CO
摘要:This invention relates to processes for the synthesis of various optically active amino pyrrolidinyl stereoisomers, or enantiomers, that may be attached to quinolonecarboxylic acids or naphthyridones. Processes and essential intermediates are disclosed and claimed for the synthesis of compounds represented by the structure shown in figure BG 4-1 , below. ##STR1## where R 50 , R 6 and R 9 are defined independently and are H, --(C 1 -C 8 )alkyl, --(C 3 -C 8 )cycloalkyl, --(C 1 -C 8 )alkyl-(C 3 -C 8 )cycloalkyl, --(C 6 -C 12 aryl), --(C 1 -C 8 )alkyl-(C 6 -C 12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, (C 6 -C 12 aryl), (C 1 -C 3 )alkyl, (C 1 -C 3 ) alkoxy, halogen, trifluoromethyl; n where R 2 is --(C 1 -C 8 )alkyl, --(C 3 -C 8 )cycloalkyl, --(C 1 -C 8 )alkyl-(C 3 -C 8 )cycloalkyl, --(C 6 -C 12 aryl), --(C 1 -C 8 )alkyl-(C 6 -C 12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, --(C 6 -C 12 aryl), --(C 1 -C 3 )alkyl, --(C 1 -C 3 ) alkoxy, halogen, trifluoromethyl; n depending upon the starting materials used, compounds represented by the structure shown by figure BG 4-1 may have one of either of the two steriochemical arrangments shown, or, if the starting materials are a racemic mixture, the reaction may produce a 1:1 ratio of the combination of products shown in Figure BG 4-1 , i.e. a racemic mixture.

专利号:US-5773610-A
优先权日:1993-05-06
标 题 :Optically active 3-(1-(alkylamino))alkyl pyrrolidines
发明人：MCWHORTER WILLIAM W; FLECK THOMAS J; PEARLMAN BRUCE A
权利人:UPJOHN CO
摘要:This invention relates to processes for the synthesis of various optically active amino pyrrolidinyl stereoisomers, or enantiomers, that may be attached to quinolonecarboxylic acids or naphthyridones. Processes and essential intermediates are disclosed and claimed for the synthesis of compounds represented by the structure shown in FIG. BG 4-1 , where R 50 , R 6 and R 9 are defined independently and are H, -(C 1 -C 8 )alkyl, -(C 3 -C 8 )cycloalkyl, -(C 1 -C 8 )alkyl-(C 3 -C 8 )cycloalkyl, -(C 6 -C 12 aryl), -(C 1 -C 8 )alkyl-(C 6 -C 12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, (C 6 -C 12 aryl), (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, halogen, trifluoromethyl; where R 2 is -(C 1 -C 8 )alkyl, -(C 3 -C 8 )cycloalkyl, -(C 1 -C 8 )alkyl-(C 3 -C 8 )cycloalkyl, -(C 6 -C 12 aryl), -(C 1 -C 8 )alkyl-(C 6 -C 12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, -(C 6 -C 12 aryl), -(C 1 -C 3 )alkyl,-(C 1 -C 3 )alkoxy, halogen, trifluoromethyl; depending upon the starting materials used, compounds represented by the structure shown by FIG. BG 4-1 may have one of either of the two stereochemical arrangements shown, or, if the starting materials are a racemic mixture, the reaction may produce a 1:1 ratio of the combination of products shown in FIG. BG 4-1 , i.e. a racemic mixture.

专利号:US-5962697-A
优先权日:1993-05-06
标题:Optically active 3-(1-(alkylamino))alkyl pyrrolidines
发明人：FLECK THOMAS J; PEARLMAN BRUCE A; MCWHORTER JR WILLIAM W
权利人:UPJOHN CO
摘要:This invention relates to processes for the synthesis of various optically active amino pyrrolidinyl stereoisomers, or enantiomers, that may be attached to quinolonecarboxylic acids or naphthyridones. Processes and essential intermediates are disclosed and claimed for the synthesis of compounds represented by the structure shown in figure BG 4-1 , below. ##STR1## where R 50 , R 6 and R 9 are defined independently and are H, --(C 1 -C 8 )alkyl, --(C 3 -C 8 )cycloalkyl, --(C 1 -C 8 )alkyl-(C 3 -C 8 )cycloalkyl, --(C 6 -C 12 aryl), --(C 1 -C 8 ) alkyl-(C 6 -C 12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, (C 6 -C 12 aryl), (C 1 -C 3 )alkyl, (C 1 -C 3 ) alkoxy, halogen, trifluoromethyl; n where R 2 is --(C 1 -C 8 )alkyl, --(C 3 -C 8 )cycloalkyl, --(C 1 -C 8 )alkyl-(C 3 -C 8 )cycloalkyl, --(C 6 -C 12 aryl), --(C 1 -C 8 )alkyl-(C 6 -C 12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, --(C 6 -C 12 aryl), --(C 1 -C 3 )alkyl, --(C 1 -C 3 ) alkoxy, halogen, trifluoromethyl; n depending upon the starting materials used, compounds represented by the structure shown by figure BG 4-1 may have one of either of the two steriochemical arrangments shown, or, if the starting materials are a racemic mixture, the reaction may produce a 1:1 ratio of the combination of products shown in Figure BG 4-1 , i.e. a racemic mixture.