CAS: 52950-37-5; (S)-4-Amino-3-Phenylbutanoic Acid Hydrochloride

相似化合物

3060-41-1 62596-63-8 189014-01-5

上下游产品

4-phenylpyrrolidin-2-one α-phenyl-β-benzoyl-γ-nitrobutyrate ethyl ester 4-amino-3-phenylbutanoic acid methyl ester 3-phenylglutaronitrile 4-phenyl-1-(trimethylsilyl)-2-pyrrolidinone (4R)-4-phenyl-2-pyrrolidone 2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester

📜3-Phenylpent-4-Enoic Acid置于盐酸,4-二甲氨基吡啶,Sodium Azide,Pseudomonas Cepacia Lipase,18-冠醚-6,Palladium On Activated Charcoal,氢气,Sodium Cyanoborohydride,臭氧,1,8-二氮杂双环[5.4.0]十一碳-7-烯,三乙胺体系中,用 乙醇,二氯甲烷,水,溶剂黄146,乙酸乙酯 作为反应溶剂,化学反应 136.83H,反应生成 (3S)-4-氨基-3-苯基丁酸盐酸盐
参考文献:Studies On The Chemoenzymatic Synthesis Of 3-Phenyl-Gaba And 4-Phenyl-Pyrrolid-2-One: The Influence Of Donor Of The Alkoxy Group On Enantioselective Esterification
标题:Studies On The Chemoenzymatic Synthesis Of 3-Phenyl-Gaba And 4-Phenyl-Pyrrolid-2-One: The Influence Of Donor Of The Alkoxy Group On Enantioselective Esterification
摘要:A New Chemoenzymatic Method For The Synthesis Of Enantiomerically Pure 3-Phenyl-Gamma-Aminobutyric Acid 1 And 4-Phenyl-Pyrrolid-2-One 9 Based On The Enzymatic Kinetic Resolution Of 3-Phenyl-4-Pentenoic Acid 2 Is Described Herein. Enzymatic Resolution Of The Racemic Substrate Provided Products With Good Enantiselectivity Upon Esterification. In These Reactions,A New Class Of Alkoxy Group Donor-Orthoesters,Acetals And Ketals Were Used. The Best Results Of The Enzymatic Kinetic Resolution Were Obtained For Triethyl Orthoacetate In Toluene Solvent. Crown Copyright (C) 2013 Published By Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetasy.2013.02.016