CAS: 50413-24-6; 2-Bromo-1-(4-(Methylsulfonyl)Phenyl)Ethanone

上下游产品

CAS号10297-73-1 4-甲砜基苯乙酮 | CAS号42445-46-5 2-溴-4'-甲硫基苯乙酮 | CAS号1778-09-2 4-甲硫基苯乙酮 | CAS号75-09-2 二氯甲烷 | CAS号7732-18-5 水 | CAS号98-86-2 苯乙酮 | CAS号21382-98-9 4-甲硫基氰苯 | CAS号100-68-5 茴香硫醚 | CAS号201737-94-2 [2-(4-methylsul... | CAS号263242-00-8 2-(2,4-difluoro... | CAS号3458-56-8 2-(4-(METHYLSUL... | CAS号162011-90-7 罗非昔布 | CAS号162011-83-8 3-(3,4-Difluoro... | CAS号157672-00-9 4-(4-氟苯基)-3-(4-... | CAS号197240-27-0 2-HYDROXY-1-(4-...

茴香硫醚置于三氯化铝,溴体系中,用 甲醇,二氯甲烷,氯仿 作为反应溶剂,化学反应 4.5H,反应生成 2-溴-1-(4-甲磺酰基)苯乙酮
参考文献:Synthesis Of Rofecoxib,(Mk 0966,Vioxx® 4-(4'-Methylsulfonylphenyl)-3-Phenyl-2(5H)-Furanone),A Selective And Orally Active Inhibitor Of Cyclooxygenase-2
标题:Synthesis Of Rofecoxib,(Mk 0966,Vioxx® 4-(4'-Methylsulfonylphenyl)-3-Phenyl-2(5H)-Furanone),A Selective And Orally Active Inhibitor Of Cyclooxygenase-2
摘要:本文介绍了 Vioxx® (罗非昔布,Mk 966,4-(4'甲基磺酰基苯基)-3-苯基-2(5H)-呋喃酮)的合成过程,它是一种新近获得美国 Fda 批准的环氧化酶-2 抑制剂.
DOI:10.1055/s-2001-17519

专利信息

专利号:US-5684195-A
优先权日:1994-07-14
标 题:Method of preparing sulfmonamides from sulfones
发明人：HUANG HORNG-CHIH; HARRING SCOTT R
权利人:SEARLE & CO
摘要:A one-pot synthesis of sulfonamides from sulfones has been developed. Conversion of sulfones to the corresponding sulfinic acid salts is followed by oxidative-amination to give the sulfonamides.

专利号:US-8829014-B2
优先权日:2006-04-07
标题 :Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
发明人：GIORDANO ANTHONY; VASU KAMALA K; THAKAR HARDIK M; GIRI RAJAN S; SUDARSANAM VASUDEVAN; YERANDE SWAPNIL G; INAMDAR GAJANAN S
权利人:GIORDANO ANTHONY; VASU KAMALA K; THAKAR HARDIK M; GIRI RAJAN S; SUDARSANAM VASUDEVAN; YERANDE SWAPNIL G; INAMDAR GAJANAN S; UNIV LOUISIANA STATE; PATEL PHARMACEUTICAL EDUCATION & RES DEV PERD CT B V
摘要:Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.